||FUNCTION: Associates specifically with huntingtin. This binding is enhanced by an expanded polyglutamine repeat. ALTERNATIVE PRODUCTS: 2 named isoforms produced by alternative splicing. TISSUE SPECIFICITY: In the brain, especially in the olfactory bulb and in the brain stem. No detectable expression in peripheral tissues such as lung, testis, spleen, and small intestine. SIMILARITY: Contains 1 HAP1 N-terminal domain.
||See product label
||Recombinant rat HAP-1
||Huntingtin-associated protein 1; HAP1
||IHC. A dilution of 1:500 to 1:3000 is recommended for this application. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
||Specificity for HAP-1 was confirmed by IHC.
||This antiserum is known to react with rat HAP-1. Other species have not yet been tested.
||If you would like to see the shared identity between different species or other proteins follow the link in Accession field, select then the sequence (make sure that you are selecting the sequence that you are interested in, as the sequence may be the precursor rather than the mature protein for example) and copy and paste it HERE and blast/format it.
||Reconstitute in 100 uL of sterile water. Centrifuge to remove any insoluble material.
||After reconstitution keep aliquots at -20C for a higher stability, and at 2-8C with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.
||1. Zhou, H. et al. (2003). J. Cell Biol. 163(1): 109-118.
2. Fusco, F.R. et al. (2003). Eur. J. Neurosci. 18: 1-10.
3. Pardo, R. et al. (2006). J. Neurosci. 26(5): 1635-1645.
4. Harper, S. Q. et al. (2005). Proc. Nat. Acad. Sci. (USA) 102: 5820-5825.
5. Qin, Z. et al. (2004). J. Neurosci. 24(1): 269-281.
6. Tang, T. S. et al. (2003). Neuron 39(2): 227-239.