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Rabbit antibody to Synphilin-1 (829-847): whole serum


Catalogue No. R-116-100
Description Synuclein alpha interacting protein (Synphilin-1) contains several protein-protein interaction domains and interacts with alpha synuclein in neurons. Mutations of SNCAIP have been linked to Parkinson disease. The amino acid sequence of synphilin-1 shares a high level of identity with its human counterpart, particularly in regions containing ankyrin-like motifs and the coiled-coil domain. Expression pattern of synphilin-1 in tissues is similar in both mouse and human. Synphilin-1 has an important role in the formation of aggregates and cytotoxicity in Parkinson disease and also Dorfin may be involved in the pathogenic process by ubiquitylation of synphilin-1.
Batch No. See product label
Unit size 100 uL
Antigen A synthetic peptide (SLELNGEKDKDKGRTLQRT) as part of human synphilin-1a conjugated to KLH has been used as the immunogen.
Other Names Synphilin-1a protein; synuclein alpha interacting protein; Synphilin-1; Synphilin 1; SNCAIP
Accession Synphilin-1a protein_HUMAN
Produced in Rabbit
Purity Whole serum
Applications IHC. A dilution of 1: 1000 to 1:2000 is recommended for this application. This antiserum will stain Lewy bodies in Dorsal raphe nucleus of Parkinson's diseased human brain. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
Specificity A high level of specificity has been shown for this antiserum by IHC on human brain.
Cross-reactivity This antiserum is known to react with rat and human synphilin-1a.
Blast it If you would like to use this product in another species other than those specified here, or to see the shared identity between the immunogen used here in different speices and/or other molecules, simply copy the immunogen (from the Immunogen field) and paste it HERE and blast/format it. Note that, antisera raised against synthetic peptides are quite often very specific for that peptide ie, only one single amino acid difference may be enough to restrict the specificity to a particular molecule. Regardless, you can always contact us if you need assistance with this.
Form Lyophilised
Reconstitution Reconstitute in 100 uL of sterile water. Centrifuge to remove any insoluble material.
Storage After reconstitution keep aliquots at -20C for a higher stability, and at 2-8C with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.
Expiry Date 12 months after purchase
References 1. Kruger,R. Cell Tissue Res. 318 (1), 195-199 (2004)
2. Lee,G., etal. J. Biol. Chem. 279 (8), 6834-6839 (2004)
3. Tanaka,M., et al. J. Biol. Chem. 279 (6), 4625-4631 (2004)
4. Nagano,Y., et al. J. Biol. Chem. 278 (51), 51504-51514 (2003)
5. Marx,F.P., etal. Hum. Mol. Genet. 12 (11), 1223-1231 (2003)
6. Junn,E., et al. J. Biol. Chem. 277 (49), 47870-47877 (2002)
7. Chung,K.K., et al. Nat. Med. 7 (10), 1144-1150 (2001)
8. Kawamata,H., et al. J. Neurochem. 77 (3), 929-934 (2001)
9. Engelender,S., et al. Nat. Genet. 22 (1), 110-114 (1999)
Images (click to zoom)
Rabbit antibody to Synphilin-1 (829-847): whole serum Immunohistochemical staining of synphilin-1 positive Lewy bodies in dorsal rache nucleus in a case of Parkinson’s disease using rabbit polyclonal antibody to human synphilin-1, catalogue number R-116-100.

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