| Catalogue No. |
R-1559-100 |
| Description |
The Receptor for Advanced Glycation Endproducts (RAGE) is also known as the Advanced glycosylation end product-specific receptor (AGER). RAGE is expressed in endothelial cells and interacts with many molecules including advanced glycosylation end products (AGE) and amyloid beta peptide. At least 2 RAGE isoforms are produced by alternative splicing. Isoform 1 is a single-pass type I membrane protein whereas isoform 2 is secreted. |
| Batch No. |
See product label |
| Unit size |
100 ug |
| Antigen |
A synthetic peptide corresponding to a region (178-196 aa) from human RAGE. |
| Other Names |
AGER; RAGE; |
| Accession |
Q15109 RAGE_HUMAN; |
| Produced in |
Rabbit |
| Applications |
Immunohistochemistry (IHC) and Western Blotting (WB). A concentration of 1.0ug/mL is recommended for WB. Human RAGE (isoform 1) has a predicted length of 404 residues and MW of 43 kDa. A concentration of 1.0 ug/mL is recommended to detect the protein in formalin fixed and paraffin embedded tissues. Heat mediated antigen retrieval is recommended. Biosensis recommends optimal dilutions/concentrations should be determined by the end user. |
| Specificity |
The specificity of this antibody has been confirmed by WB and IHC against the antigen. |
| Cross-reactivity |
Human (WB, IHC), Rat (IHC). Predicted to react with mouse due to sequence homology |
| Blast URL |
Click here |
| Form |
Lyophilised with 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3 |
| Reconstitution |
Reconstitute in 100 uL of sterile distilled water to achieve an antibody concentration of 1 mg/mL. Centrifuge to remove any insoluble material. |
| Storage |
At least 12 months after purchase at 2-8C (lyophilized formulations). After reconstitution, aliquot and store at -20C for a higher stability. Avoid freeze-thaw cycles |
| Expiry Date |
12 months after purchase |
