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Ruxolitinib (25 mg)


Catalogue No. PE-1857-25
Description Pharmacology: Potent and selective JAK1&2 inhibitor, IC50s=2.7, 4.5 and 322 nM for JAK1, JAK2 and JAK3 respectively (1). Blocks IL-6 signaling (IC50=281 nM) and proliferation of JAK2V617F+ Ba/F3 cells (IC50=127 nM) (2). Inhibits the proinflammatory secretome of senescent cells (3). The JAK1 S646P mutant is sensitive to ruxolitinib (4). Clinically useful anticancer agent. PubChem CID: 2512798

Product is sold for research use only. Not for human therapeutic use or for medicinal purposes.
Batch No. See product label.
Unit size 25 mg
Other Names INCB018424; CAS #:941678-49-5; INCB-018424
Molecular Weight 306.4 g/mol. Molecular F306.4ormula: C17H18N6
Compound Name (3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile
Purity >98% (HPLC); NMR (Conforms)
Biol. activity Ruxolitinib is an orally bioavailable Janus-associated kinase (JAK) inhibitor with potential antineoplastic and immunomodulating activities. Ruxolitinib specifically binds to and inhibits protein tyrosine kinases JAK 1 and 2, which may lead to a reduction in inflammation and an inhibition of cellular proliferation. The JAK-STAT (signal transducer and activator of transcription) pathway plays a key role in the signaling of many cytokines and growth factors and is involved in cellular proliferation, growth, hematopoiesis, and the immune response; JAK kinases may be upregulated in inflammatory diseases, myeloproliferative disorders, and various malignancies.
Applications Biochemical inhibition.
Appearance Dry, white powder.
Reconstitution Soluble in DMSO. May be dissolved in DMSO up to 28 mg/mL or 15 mg/mL ethanol
Storage Store desiccated as supplied at -20C for up to 2 years. Store solutions at -20C for up to 1 month. Prevent multiple freeze-thaw cycles.
Expiry Date See storage conditions.
General References 1. S Verstovsek et al. Hematol. Am. Soc. Hematol. Educ. Program 2009 2009(1)636
2. A Quintas-Cardama et al. Blood 2010 115:3109
3. JN Farr et al. Nat. Med. 2017 23:1072
4. Q Li et al. Oncotarget 2017 8:34687
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Ruxolitinib (25 mg)

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