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Sheep antibody to human C-reactive protein: whole serum


Catalogue No. S-071-100
Description C-reactive protein has several roles associated with host defence such as; promoting agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. It can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. COFACTOR: Binds 2 calcium ions per subunit. C-reactive protein exists as a homopentamer. Pentaxin (or Pentraxin) have a discoid arrangement of 5 non-covalently bound subunits. There are 2 alternatively spliced isoforms. C-reactive protein is found in plasma and its concentration increases greatly during acute phase response to tissue injury, infection or other inflammatory stimuli. It is induced by IL-1 and IL-6.
Batch No. See product label
Unit size 100 uL
Antigen Human recombinant C-Reactive protein
Other Names CRP; PTX1
Accession CRP_HUMAN
Produced in Sheep
Purity Whole serum
Applications WB. Extremely high titre antibody. For western blot a dilution of 1: 10,000 to 1: 100000 is recommended. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
Specificity It has been shown to be specific for C-reactive protein by WB.
Cross-reactivity Human, other species have not yet been tested.
Blast it If you would like to see the shared identity between different species or other proteins follow the link in Accession field, select then the sequence (make sure that you are selecting the sequence that you are interested in, as the sequence may be the precursor rather than the mature protein for example) and copy and paste it HERE and blast/format it.
Form Lyophilised with 0.01% Thimerosal
Reconstitution Reconstitute in 100 uL of sterile water. Centrifuge to remove any insoluble material.
Storage After reconstitution keep aliquots at -20C for a higher stability, and at 2-8C with an appropriate antibacterial agent.
Expiry Date 12 months after purchase
References 1. Lei K.-J, et al. J. Biol. Chem. 260:13377-13383(1985).
2. Woo P, et al. J. Biol. Chem. 260:13384-13388(1985).
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