Synphilin-1 (Sph1), Rabbit Polyclonal Antibody

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Catalog Number
R-117

    Product Info

  • Product Name Synphilin-1 (Sph1), Rabbit Polyclonal Antibody
  • Product Description google Rabbit anti-Synphilin-1 (Sph1) Polyclonal Antibody (Unconjugated), suitable for WB, IHC-Frozen.
  • Alternative Names Synphilin-1a protein; synuclein alpha interacting protein; Synphilin-1; Synphilin 1; SNCAIP
  • Application(s) IHC-Frozen, WB
  • Antibody Host Rabbit
  • Antibody Type Polyclonal
  • Specificity A high level of specificity has been shown for this antiserum by IHC on human brain. This antiserum is known to react with rat and human synphilin-1a.
  • Species Reactivity Human, Rat
  • Immunogen Description A synthetic peptide (CASKGKNKAA) as part of human synphilin-1a conjugated to KLH has been used as the immunogen.
  • Conjugate Unconjugated
  • Purity Description Whole serum
  • Regulatory Status For research use only.

    Specifications

  • Product Description Rabbit anti-Synphilin-1 (Sph1) Polyclonal Antibody (Unconjugated), suitable for WB, IHC-Frozen.
  • Application(s) IHC-Frozen, WB
  • Application Details IHC, WB. A dilution of 1: 1000 to 1:2000 is recommended for immunohistochemistry and 1:500-1:1000 for western blot. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
  • Target Synphilin-1 (Sph1)
  • Specificity A high level of specificity has been shown for this antiserum by IHC on human brain. This antiserum is known to react with rat and human synphilin-1a.
  • Target Host Species Human
  • Species Reactivity Human, Rat
  • Antibody Host Rabbit
  • Antibody Type Polyclonal
  • Antibody Isotype Mixed
  • Conjugate Unconjugated
  • Immunogen Description A synthetic peptide (CASKGKNKAA) as part of human synphilin-1a conjugated to KLH has been used as the immunogen.
  • Purity Description Whole serum
  • Format Lyophilized
  • Reconstitution Instructions Spin vial briefly before opening. Reconstitute in 100 µL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material.
  • Storage Instructions After reconstitution keep aliquots at -20°C for a higher stability, and at 2-8°C with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.
  • Batch Number Please see item label.
  • Expiration Date 12 months after date of receipt (unopened vial).
  • Alternative Names Synphilin-1a protein; synuclein alpha interacting protein; Synphilin-1; Synphilin 1; SNCAIP
  • Uniprot Number Q6L986
  • Uniprot Number/Name Q9Y6H5 (SNCAP_HUMAN)
  • Scientific Background Synuclein alpha interacting protein (Synphilin-1) contains several protein-protein interaction domains and interacts with alpha synuclein in neurons. Mutations of SNCAIP have been linked to Parkinson disease. The amino acid sequence of synphilin-1 shares a high level of identity with its human counterpart, particularly in regions containing ankyrin-like motifs and the coiled-coil domain. Expression pattern of synphilin-1 in tissues is similar in both mouse and human. Synphilin-1 has an important role in the formation of aggregates and cytotoxicity in Parkinson disease and also Dorfin may be involved in the pathogenic process by ubiquitylation of synphilin-1.
  • Shipping Temperature 25°C (ambient)
  • UNSPSC CODE 41116161
  • Regulatory Status For research use only.

    Images, Protocols & SDS

    Citations & References

  • General References Kruger,R. Cell Tissue Res. 318 (1), 195-199 (2004)
    Lee,G., etal. J. Biol. Chem. 279 (8), 6834-6839 (2004)
    Tanaka,M., et al. J. Biol. Chem. 279 (6), 4625-4631 (2004)
    Nagano,Y., et al. J. Biol. Chem. 278 (51), 51504-51514 (2003)
    Marx,F.P., etal. Hum. Mol. Genet. 12 (11), 1223-1231 (2003)
    Junn,E., et al. J. Biol. Chem. 277 (49), 47870-47877 (2002)
    Chung,K.K., et al. Nat. Med. 7 (10), 1144-1150 (2001)
    Kawamata,H., et al. J. Neurochem. 77 (3), 929-934 (2001)
    Engelender,S., et al. Nat. Genet. 22 (1), 110-114 (1999)