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Synuclein, pan, Rabbit Polyclonal Antibody
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Catalog Number
R-060
- Product Name Synuclein, pan, Rabbit Polyclonal Antibody
- Product Description Rabbit anti-Pan-synuclein Polyclonal Antibody (Unconjugated), suitable for WB, IHC-Frozen.
- Application(s) IHC-Frozen, WB
- Antibody Host Rabbit
- Antibody Type Polyclonal
- Specificity Overlap specific immunohistochemical staining of alpha-, beta- and gamma synucleins This antiserum recognises human and rat alpha-, beta- and gamma synucleins.
- Species Reactivity Human, Rat
- Immunogen Description A synthetic peptide (AKEGVVAAAEKTKQGV) as a consensus part of human alpha-, beta-, and gamma synuclein proteins conjugated to diphteria toxoid has been used as the immunogen.
- Conjugate Unconjugated
- Purity Description Whole serum
- Regulatory Status For research use only.
Product Info
- Product Description Rabbit anti-Pan-synuclein Polyclonal Antibody (Unconjugated), suitable for WB, IHC-Frozen.
-
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- Application(s) IHC-Frozen, WB
- Application Details IHC, WB and immunoblot. A dilution of 1:1000 is recommended for these applications. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
- Target Pan-synuclein
- Specificity Overlap specific immunohistochemical staining of alpha-, beta- and gamma synucleins This antiserum recognises human and rat alpha-, beta- and gamma synucleins.
- Target Host Species Human
- Species Reactivity Human, Rat
- Antibody Host Rabbit
- Antibody Type Polyclonal
- Antibody Isotype Mixed
- Conjugate Unconjugated
- Immunogen Description A synthetic peptide (AKEGVVAAAEKTKQGV) as a consensus part of human alpha-, beta-, and gamma synuclein proteins conjugated to diphteria toxoid has been used as the immunogen.
- Purity Description Whole serum
- Format Lyophilized
- Reconstitution Instructions Spin vial briefly before opening. Reconstitute in 100 µL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material.
- Storage Instructions After reconstitution keep aliquots at -20°C for a higher stability, and at 2-8°C with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.
- Batch Number Please see item label.
- Expiration Date 12 months after date of receipt (unopened vial).
- Uniprot Number P37840; Q16143; O76070
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Uniprot Number/Name
P37840 (SYUA_HUMAN)
Q16143 (SYUB_HUMAN)
O76070 (SYUG_HUMAN) - Scientific Background Detects human alpha-, beta-, and gamma synuclein proteins. A family of homologous proteins known as alpha-, beta-, and gamma-synuclein are abundantly expressed in brain, especially in the presynaptic terminal of neurons. Although the precise function of these proteins remains unknown, alpha-synuclein has been implicated in synaptic plasticity associated with avian song learning as well as in the pathogenesis of Parkinson's disease (PD), dementia with LBs (DLB), some forms of Alzheimer's disease (AD), and multiple system atrophy (MSA).
- Shipping Temperature 25°C (ambient)
- UNSPSC CODE 41116161
- Regulatory Status For research use only.
Specifications
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Specific References
Ulusoy A. et al (2010) Eur J Neurosci. 2010 Aug;32(3):409-22
Naesstrom T. et al (2010) The lipid peroxidation products 4-oxo-2-nonenal and 4-hydroxy-2-nonenal promote the formation of _-synuclein oligomers with distinct biochemical, morphological, and functional properties. Free Radic Biol Med. 2010 Dec 1.
Eslamboli A. et al (2007) Long-term consequences of human alpha-synuclein overexpression in the primate ventral midbrain. Brain. 2007 Mar;130(Pt 3):799-815.
Mukaetova-Ladinska E.B. et al (2008) Alpha- and gamma-synuclein proteins are present in cerebrospinal fluid and are increased in aged subjects with neurodegenerative and vascular changes. Dement Geriatr Cogn Disord. 2008;26(1):32-42.
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General References
Lundvig, et al Brain Res Mol Brain Res 134, 3-17 (Mar 24, 2005).
Bennett, Pharmacol Ther 105, 311-31 (Mar, 2005).
Vekrellis, et al., Mol Neurobiol 30, 1-21 (Aug, 2004).
Martin, et al., Protein Pept Lett 11, 229-37 (Jun, 2004).
Doherty, et al., Acta Neuropathol (Berl) 107, 169-75 (Feb, 2004).
Goedert, Curr Opin Genet Dev 11, 343-51 (Jun, 2001).
Saito, et al., J Neurol Sci 177, 48-59 (Aug 1, 2000).
Lucking et al. Cell Mol Life Sci. 2000 Dec;57(13-14):1894-908.
Kahle, et al., Ann N Y Acad Sci 920, 33-41 (2000).
Clayton, et al., Trends Neurosci 21, 249-54 (Jun, 1998).