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DJ-1/PARK7, Rabbit Polyclonal Antibody
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Catalog Number
R-1682
- Product Name DJ-1/PARK7, Rabbit Polyclonal Antibody
- Product Description Rabbit anti-DJ-1/PARK7 Polyclonal Antibody (Unconjugated), suitable for WB.
- Alternative Names PARK7
- Application(s) WB
- Antibody Host Rabbit
- Antibody Type Polyclonal
- Specificity Confirmed by WB using soluble mouse and human brain extracts, reactivity for major product diminished by peptide absorption.
- Species Reactivity Human, Mouse
- Immunogen Description A synthetic peptide (ASKRALVILAKGAEE-C) corresponding to human DJ-1 [2-16] in the N-terminal domain conjugated via additional C-terminal Cys to Diphtheria toxoid.
- Conjugate Unconjugated
- Purity Description Protein G purified IgG
- Regulatory Status For research use only.
Product Info
- Product Description Rabbit anti-DJ-1/PARK7 Polyclonal Antibody (Unconjugated), suitable for WB.
- Application(s) WB
- Application Details WB and IHC. Suggested dilution of 1:5,000 is recommended for WB. DJ-1 is a soluble protein of 189 amino acids and detected with 23 kDa mobility by western blotting. The suggested dilution for IHC is 1:100. Detected astrocyte cytoplasmic labelling in human brain formaldehyde-treated tissue. Biosensis recommends that the optimal working dilution should be determined by the end user.
- Target DJ-1/PARK7
- Specificity Confirmed by WB using soluble mouse and human brain extracts, reactivity for major product diminished by peptide absorption.
- Target Host Species Human
- Species Reactivity Human, Mouse
- Antibody Host Rabbit
- Antibody Type Polyclonal
- Antibody Isotype IgG
- Conjugate Unconjugated
- Immunogen Description A synthetic peptide (ASKRALVILAKGAEE-C) corresponding to human DJ-1 [2-16] in the N-terminal domain conjugated via additional C-terminal Cys to Diphtheria toxoid.
- Purity Description Protein G purified IgG
- Format Lyophilized from PBS, pH 7.4. Contains no preservative.
- Reconstitution Instructions Spin vial briefly before opening. Reconstitute in 500 µL sterile-filtered 1X PBS, pH 7.2-7.6. Centrifuge to remove any insoluble material.
- Storage Instructions Short term storage at 2-8°C for one week. At -20°C as an undiluted liquid for up to 12 months.
- Batch Number Please see item label.
- Expiration Date 12 months after date of receipt (unopened vial).
- Alternative Names PARK7
- Uniprot Number Q99497
- Uniprot Number/Name Q99497 (PARK7_HUMAN)
- Scientific Background Autosomal recessive mutations in DJ-1 cause early-onset familial Parkinson's disease. DJ-1 is considered a redox-sensitive cytoplasmic protein found in brain as well as other cell types.
- Shipping Temperature 25°C (ambient)
- UNSPSC CODE 41116161
- Regulatory Status For research use only.
Specifications
- General References Sonia George, Su San Mok, Milawaty Nurjono, Scott Ayton, David I. Finkelstein, Colin L. Masters,Qiao-Xin Li & Janetta G. Culvenor (2010) alpha-Synuclein Transgenic Mice Reveal Compensatory Increases in Parkinson's Disease-Associated Proteins DJ-1and Parkin and Have Enhanced alpha-Synuclein and PINK1 Levels After Rotenone Treatment J Mol Neurosci 42:243_254