Ciliary neurotrophic factor (CNTF), Chicken Polyclonal Antibody

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Catalog Number
C-1526

    Product Info

  • Product Name Ciliary neurotrophic factor (CNTF), Chicken Polyclonal Antibody
  • Product Description google Chicken anti-Ciliary neurotrophic factor (CNTF) Polyclonal Antibody (Unconjugated), suitable for WB, ELISA.
  • Alternative Names Ciliary neurotrophic factor; CNTF;
  • Application(s) ELISA, WB
  • Antibody Host Chicken
  • Antibody Type Polyclonal
  • Specificity CNTF, Cross reactivity to other species is expected
  • Species Reactivity Human, Mouse, Rat
  • Immunogen Description Mixture of two peptides from human CNTF (11-25 and 186-200 aa). Both peptides are highly conserved among human and mouse.
  • Conjugate Unconjugated
  • Purity Description Affinity-purified
  • Regulatory Status For research use only.

    Specifications

  • Product Description Chicken anti-Ciliary neurotrophic factor (CNTF) Polyclonal Antibody (Unconjugated), suitable for WB, ELISA.
  • Application(s) ELISA, WB
  • Application Details WB and ELISA at a suggested dilution of 1:500 to 1:2,000. A titration between 1:50 to 1:500 is suggested for IHC. Biosensis recommends that the optimal working dilution should be determined by the end user.
  • Target Ciliary neurotrophic factor (CNTF)
  • Specificity CNTF, Cross reactivity to other species is expected
  • Target Host Species Human
  • Species Reactivity Human, Mouse, Rat
  • Antibody Host Chicken
  • Antibody Type Polyclonal
  • Antibody Isotype IgY
  • Conjugate Unconjugated
  • Immunogen Description Mixture of two peptides from human CNTF (11-25 and 186-200 aa). Both peptides are highly conserved among human and mouse.
  • Sequence PHRRDLCSRSIWLAR and IPARGSHYIANNKKM
  • Purity Description Affinity-purified
  • Format Liquid. PBS with 0.02% Sodium Azide
  • Storage Instructions Short term storage at 2-8°C for one week. At -20°C as an undiluted liquid for up to 12 months.
  • Batch Number Please see item label.
  • Expiration Date 12 months after date of receipt (unopened vial).
  • Alternative Names Ciliary neurotrophic factor; CNTF;
  • Uniprot Number P26441
  • Uniprot Number/Name P26441 (CNTF_HUMAN)
  • Scientific Background CNTF is a survival promoting factor for different types of neurons in vitro and in vivo. The essential structural features for the biological function of human CNTF were investigated by Thier, M. et al. They showed that deletion of 14 N-terminal and 18 C-terminal amino acids significantly increased bioactivity compared to wild-type CNTF. FUNCTION: CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy. SUBUNIT: Homodimer. SUBCELLULAR LOCATION: Cytoplasm. TISSUE SPECIFICITY: Nervous system. PHARMACEUTICAL: CNTF is being tested under the name Axokine by Regeneron Pharmaceuticals for treatment of human motor neuron diseases, such as amyotrophic lateral sclerosis (ALS). As it induces substantial weight loss, preferentially of fat as opposed to lean body mass, it is being used for obesity treatment. SIMILARITY: Belongs to the CNTF family.
  • Shipping Temperature 2-8°C (on cold packs)
  • UNSPSC CODE 41116161
  • Regulatory Status For research use only.

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