Cyclooxygenase-2 (COX-2), Rabbit Polyclonal Antibody

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Catalog Number
R-1114
Discontinued

    Product Info

  • Product Name Cyclooxygenase-2 (COX-2), Rabbit Polyclonal Antibody
  • Product Description google Rabbit anti-Cyclooxygenase-2 (COX-2) Polyclonal Antibody (Unconjugated), suitable for WB, IHC-Frozen, IHC-Paraffin-embedded.
  • Alternative Names Prostaglandin G/H synthase 2; EC 1.14.99.1; Cyclooxygenase-2; COX-2; Prostaglandin-endoperoxide synthase 2; Prostaglandin H2 synthase 2; PGH synthase 2; PGHS-2; PHS II; PTGS2; COX2;
  • Application(s) IHC-Frozen, IHC-Paraffin-embedded, WB
  • Antibody Host Rabbit
  • Antibody Type Polyclonal
  • Specificity The specificity of this antibody has been confirmed by WB and IHC against the antigen. Human; rat; predicted to react with mouse due to sequence homology;
  • Species Reactivity Human, Mouse (Predicted), Rat
  • Immunogen Description A synthetic peptide (NRGVCMSVGFDQYKCDCTRTGFY) corresponding to a region (28-50) from human Cyclooxygenase-2. To enhance the immunological response, this peptide was coupled to carrier protein BSA.
  • Conjugate Unconjugated
  • Purity Description Affinity purified on antigen column
  • Regulatory Status For research use only.

    Specifications

  • Product Description Rabbit anti-Cyclooxygenase-2 (COX-2) Polyclonal Antibody (Unconjugated), suitable for WB, IHC-Frozen, IHC-Paraffin-embedded.
  • Application(s) IHC-Frozen, IHC-Paraffin-embedded, WB
  • Application Details Immunohistochemistry (IHC) and Western Blotting (WB). A concentration of 1.0 µg/mL is recommended for WB. Human COX-2 (precursor) has a predicted length of 604 residues and MW of 69 kDa. A concentration of 1.0-2.0 µg/mL is recommended to detect the protein in formalin fixed and paraffin embedded tissues. Heat activated antigen retrieval is required. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
  • Target Cyclooxygenase-2 (COX-2)
  • Specificity The specificity of this antibody has been confirmed by WB and IHC against the antigen. Human; rat; predicted to react with mouse due to sequence homology;
  • Target Host Species Human
  • Species Reactivity Human, Mouse (Predicted), Rat
  • Antibody Host Rabbit
  • Antibody Type Polyclonal
  • Antibody Isotype IgG
  • Conjugate Unconjugated
  • Immunogen Description A synthetic peptide (NRGVCMSVGFDQYKCDCTRTGFY) corresponding to a region (28-50) from human Cyclooxygenase-2. To enhance the immunological response, this peptide was coupled to carrier protein BSA.
  • Purity Description Affinity purified on antigen column
  • Format Lyophilized with 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg NaN3
  • Reconstitution Instructions Spin vial briefly before opening. Reconstitute in 100 µL sterile-filtered, ultrapure water to achieve an antibody concentration of 1 mg/mL. Centrifuge to remove any insoluble material.
  • Storage Instructions At least 12 months after purchase at 2-8°C (lyophilized formulations). After reconstitution, aliquot and store at -20°C for a higher stability. Avoid freeze-thaw cycles
  • Batch Number Please see item label.
  • Expiration Date 12 months after date of receipt (unopened vial).
  • Alternative Names Prostaglandin G/H synthase 2; EC 1.14.99.1; Cyclooxygenase-2; COX-2; Prostaglandin-endoperoxide synthase 2; Prostaglandin H2 synthase 2; PGH synthase 2; PGHS-2; PHS II; PTGS2; COX2;
  • Uniprot Number P35354
  • Uniprot Number/Name P35354 (PGH2_HUMAN)
  • Scientific Background Cyclooxygenase (COX) is an important enzyme in the conversion of arachidonic acid to Prostaglandin H2, the precursor of the series-2 prostanoids. At least 3 splice variants have been found; COX-1, COX-2 and COX-3. COX-2 is induced by cytokines and mitogens and is thought to play a role in inflammatory diseases such as rheumatoid arthritis.
  • Shipping Temperature 25°C (ambient)
  • UNSPSC CODE 41116161
  • Regulatory Status For research use only.

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