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E3 ubiquitin-protein ligase SIAH1, Mouse Polyclonal Antibody
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Catalog Number
M-867
- Product Name E3 ubiquitin-protein ligase SIAH1, Mouse Polyclonal Antibody
- Product Description Mouse anti-E3 ubiquitin-protein ligase SIAH1 Polyclonal Antibody (Unconjugated), suitable for WB, ELISA.
- Alternative Names E3 ubiquitin-protein ligase SIAH1; Seven in absentia homolog 1; Siah-1a; SIAH1; HUMSIAH
- Application(s) ELISA, WB
- Antibody Host Mouse
- Antibody Type Polyclonal
- Specificity Human. Other species have not been tested.
- Species Reactivity Human
- Immunogen Description Partial recombinant human Siah-1 (amino acids 1-110) with a GST tag.
- Conjugate Unconjugated
- Purity Description Protein G purified immunoglobulin
- Regulatory Status For research use only.
Product Info
- Product Description Mouse anti-E3 ubiquitin-protein ligase SIAH1 Polyclonal Antibody (Unconjugated), suitable for WB, ELISA.
- Application(s) ELISA, WB
- Application Details This antibody is recommended for ELISA. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
- Target E3 ubiquitin-protein ligase SIAH1
- Specificity Human. Other species have not been tested.
- Target Host Species Human
- Species Reactivity Human
- Antibody Host Mouse
- Antibody Type Polyclonal
- Antibody Isotype IgG
- Conjugate Unconjugated
- Immunogen Description Partial recombinant human Siah-1 (amino acids 1-110) with a GST tag.
- Purity Description Protein G purified immunoglobulin
- Format Liquid with 50% glycerol
- Storage Instructions Keep aliquots at -20°C for higher stability. Avoid repetitive freeze/thaw cycles.
- Batch Number Please see item label.
- Expiration Date 12 months after date of receipt (unopened vial).
- Alternative Names E3 ubiquitin-protein ligase SIAH1; Seven in absentia homolog 1; Siah-1a; SIAH1; HUMSIAH
- Uniprot Number Q8IUQ4
- Uniprot Number/Name Q8IUQ4 (SIAH1_HUMAN)
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Scientific Background
Siah-1 is a member of the seven in absentia homolog (SIAH) family. It is a E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins, including many proteins involved in transcription regulation, a cell surface receptor (DCC), cytoplasmic signal transduction molecules, an antiapoptotic protein (BAG1), a microtubule motor protein (KIF22), a protein involved in synaptic vesicle function in neurons (SYP) and a structural protein. Consequently Siah-1 is involved in many cellular processes such as apoptosis, tumor suppression, cell cycle, axon guidance, transcription regulation, spermatogenesis, and TNF-alpha signaling. It is predominantly a cytoplasmic protein but is also partially a nuclear protein. It is widely expressed at low levels and is down-regulated in advanced hepatocellular carcinomas.
- Shipping Temperature 2-8°C (on cold packs)
- UNSPSC CODE 41116161
- Regulatory Status For research use only.