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Cyclin-dependent kinase inhibitor 2A, Mouse Monoclonal Antibody
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Catalog Number
M-1209
- Product Name Cyclin-dependent kinase inhibitor 2A, Mouse Monoclonal Antibody
- Product Description Mouse anti-Cyclin-dependent kinase inhibitor 2A Monoclonal Antibody (Unconjugated), suitable for WB, IHC-Frozen, IHC-Paraffin-embedded.
- Alternative Names Cyclin-dependent kinase 4 inhibitor A; CDK4I; p16-INK4a; p16INK4A; p16-INK4; Multiple tumor suppressor 1; MTS-1; CDKN2A; CDKN2; MTS1;
- Application(s) IHC-Frozen, IHC-Paraffin-embedded, WB
- Antibody Host Mouse
- Antibody Type Monoclonal
- Specificity The specificity of this antibody has been confirmed by WB and IHC against the antigen. Human;
- Species Reactivity Human
- Immunogen Description Recombinant human Cyclin-dependent kinase inhibitor 2A
- Conjugate Unconjugated
- Purity Description IgG
- Regulatory Status For research use only.
Product Info
- Product Description Mouse anti-Cyclin-dependent kinase inhibitor 2A Monoclonal Antibody (Unconjugated), suitable for WB, IHC-Frozen, IHC-Paraffin-embedded.
- Application(s) IHC-Frozen, IHC-Paraffin-embedded, WB
- Application Details Immunohistochemistry (IHC) and Western Blotting (WB). A concentration of 0.5-1.0 µg/mL is recommended for WB. Human CDK2NA (isoform 1, p16INK4A) has a predicted length of 156 residues and MW of 17 kDa. A concentration of 1.0-2.0 µg/mL is recommended to detect the protein in formalin fixed and paraffin embedded tissues. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
- Target Cyclin-dependent kinase inhibitor 2A
- Specificity The specificity of this antibody has been confirmed by WB and IHC against the antigen. Human;
- Target Host Species Human
- Species Reactivity Human
- Antibody Host Mouse
- Antibody Type Monoclonal
- Antibody Isotype IgG
- Clone Name IMD-16
- Conjugate Unconjugated
- Immunogen Description Recombinant human Cyclin-dependent kinase inhibitor 2A
- Purity Description IgG
- Format Lyophilized from 1.2% sodium acetate, 2 mg BSA, 0.01 mg NaN3
- Reconstitution Instructions Spin vial briefly before opening. Reconstitute in 1 mL of sterile-filtered PBS (pH 7.4) to achieve an antibody concentration of 100 µg/mL. Centrifuge to remove any insoluble material.
- Storage Instructions At least 12 months after purchase at 2-8°C (lyophilized formulations). After reconstitution, aliquot and store at -20°C for a higher stability. Avoid freeze-thaw cycles.
- Batch Number Please see item label.
- Expiration Date 12 months after date of receipt (unopened vial).
- Alternative Names Cyclin-dependent kinase 4 inhibitor A; CDK4I; p16-INK4a; p16INK4A; p16-INK4; Multiple tumor suppressor 1; MTS-1; CDKN2A; CDKN2; MTS1;
- Uniprot Number P42771
- Uniprot Number/Name P42771 (CDN2A_HUMAN)
- Scientific Background The Cyclin-dependent kinase inhibitor 2A (CDK2NA) gene encodes several transcripts which differ from each other in their first exons. In spite of the structural and functional differences of these transcripts, they are all involved in cell cycle G1 control. Isoform 1, also known as p16INK4A, acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6 kinases. This antibody reacts specifically with this isoform (p16INK4A).
- Shipping Temperature 25°C (ambient)
- UNSPSC CODE 41116161
- Regulatory Status For research use only.