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Rho-associated protein kinase 1 (ROCK1), Rabbit Monoclonal Antibody
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Catalog Number
R-1791
- Product Name Rho-associated protein kinase 1 (ROCK1), Rabbit Monoclonal Antibody
- Product Description Rabbit anti-Rho-associated protein kinase 1 (ROCK1) Monoclonal Antibody (Unconjugated), suitable for IHC-Paraffin-embedded, WB.
- Alternative Names Renal carcinoma antigen NY-REN-35; Rho-associated, coiled-coil-containing protein kinase 1; Rho-associated, coiled-coil-containing protein kinase I; ROCK-I; p160 ROCK-1; p160ROCK
- Application(s) IHC-Paraffin-embedded, WB
- Antibody Host Rabbit
- Antibody Type Monoclonal
- Specificity Human, mouse and rat ROCK1.
- Species Reactivity Human, Mouse, Rat
- Immunogen Description A synthesized peptide derived from human ROCK1
- Conjugate Unconjugated
- Purity Description Affinity purified
- Regulatory Status For research use only.
Product Info
- Product Description Rabbit anti-Rho-associated protein kinase 1 (ROCK1) Monoclonal Antibody (Unconjugated), suitable for IHC-Paraffin-embedded, WB.
- Application(s) IHC-Paraffin-embedded, WB
- Application Details Western blotting 1:500-1:2000; IHC(P) 1:50-1:200, heat-mediated antigen retrieval required (20 min, citrate buffer pH 6). Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
- Target Rho-associated protein kinase 1 (ROCK1)
- Specificity Human, mouse and rat ROCK1.
- Target Host Species Human
- Species Reactivity Human, Mouse, Rat
- Antibody Host Rabbit
- Antibody Type Monoclonal
- Antibody Isotype IgG
- Conjugate Unconjugated
- Immunogen Description A synthesized peptide derived from human ROCK1
- Purity Description Affinity purified
- Format Liquid. Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02% sodium azide, 0.4-0.5 mg/mL BSA, 50% glycerol.
- Reconstitution Instructions Spin vial briefly before opening. Centrifuge to remove any insoluble material.
- Storage Instructions Antibody is shipped on blue ice. Upon receipt, aliquot and store at -20°C for a higher stability. Avoid freeze-thaw cycles.
- Batch Number Please see item label.
- Expiration Date 12 months after date of receipt (unopened vial).
- Alternative Names Renal carcinoma antigen NY-REN-35; Rho-associated, coiled-coil-containing protein kinase 1; Rho-associated, coiled-coil-containing protein kinase I; ROCK-I; p160 ROCK-1; p160ROCK
- Uniprot Number Q13464
- Uniprot Number/Name Q13464 (ROCK1_HUMAN)
- Scientific Background Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/mLC2, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress. Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Required for centrosome positioning and centrosome-dependent exit from mitosis. Plays a role in terminal erythroid differentiation. May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles. Promotes keratinocyte terminal differentiation. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization.
- Shipping Temperature 2-8°C (on cold packs)
- UNSPSC CODE 41116161
- Regulatory Status For research use only.
