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Metalloproteinase inhibitor 4, Rabbit Polyclonal Antibody
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Catalog Number
R-1107
- Product Name Metalloproteinase inhibitor 4, Rabbit Polyclonal Antibody
- Product Description Rabbit anti-Metalloproteinase inhibitor 4 Polyclonal Antibody (Unconjugated), suitable for WB.
- Alternative Names Tissue inhibitor of metalloproteinases 4; TIMP-4; TIMP4;
- Application(s) WB
- Antibody Host Rabbit
- Antibody Type Polyclonal
- Specificity The specificity of this antibody has been confirmed by WB and IHC against the antigen. Human; rat; expected to react with mouse due to sequence homology;
- Species Reactivity Human, Mouse (Predicted), Rat
- Immunogen Description A synthetic peptide (YRGHLPLRKEFVDIVQP) corresponding to a region (208-224) from the C-terminus of human Metalloproteinase inhibitor 4. To enhance the immunological response, this peptide was coupled to carrier protein BSA.
- Conjugate Unconjugated
- Purity Description Affinity purified on antigen column
- Regulatory Status For research use only.
Product Info
- Product Description Rabbit anti-Metalloproteinase inhibitor 4 Polyclonal Antibody (Unconjugated), suitable for WB.
- Application(s) WB
- Application Details Western Blotting (WB). A concentration of 0.1-0.5 µg/mL is recommended for WB. Human TIMP4 (precursor) has a predicted length of 224 residues and MW of 26 kDa. A concentration of 0.5-1.0 µg/mL is recommended to detect the protein in formalin fixed and paraffin embedded tissues. Heat mediated antigen retrieval is recommended. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
- Target Metalloproteinase inhibitor 4
- Specificity The specificity of this antibody has been confirmed by WB and IHC against the antigen. Human; rat; expected to react with mouse due to sequence homology;
- Target Host Species Human
- Species Reactivity Human, Mouse (Predicted), Rat
- Antibody Host Rabbit
- Antibody Type Polyclonal
- Antibody Isotype IgG
- Conjugate Unconjugated
- Immunogen Description A synthetic peptide (YRGHLPLRKEFVDIVQP) corresponding to a region (208-224) from the C-terminus of human Metalloproteinase inhibitor 4. To enhance the immunological response, this peptide was coupled to carrier protein BSA.
- Purity Description Affinity purified on antigen column
- Format Liquid (0.5 mL) in 50% glycerol, 0.9 mg NaCl and 0.2 mg Na2HPO4
- Reconstitution Instructions The liquid formulation should be diluted in PBS (pH 7.4)
- Storage Instructions After reconstitution, aliquot and store at -20°C for a higher stability.Avoid freeze-thaw cycles.
- Batch Number Please see item label.
- Expiration Date 12 months after date of receipt (unopened vial).
- Alternative Names Tissue inhibitor of metalloproteinases 4; TIMP-4; TIMP4;
- Uniprot Number Q99727
- Uniprot Number/Name Q99727 (TIMP4_HUMAN)
- Scientific Background The matrix metalloproteinases (MMPs) are a large family of zinc endopeptidases that degrade extracellular matrix components such as fibronectin and collagen type III. The tissue inhibitors of metalloproteinase (TIMPs) complex with these matrix metalloproteinases and irreversibly inactivate them. The TIMP proteins are homologous and are either secreted in soluble form (TIMP1, TIMP2 and TIMP4) or bind to extracellular matrix components (TIMP3). Metalloproteinase inhibitor 4 (TIMP4) is known to inhibit MMP-1, MMP-2, MMP-3, MMP-7 and MMP-9.
- Shipping Temperature 2-8°C (on cold packs)
- UNSPSC CODE 41116161
- Regulatory Status For research use only.