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Non-specific Control IgG, Mouse Monoclonal Antibody (Saporin)
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Catalog Number
M-1792-IT
- Product Name Non-specific Control IgG, Mouse Monoclonal Antibody (Saporin)
- Product Description X63-saporin is an antibody conjugate comprising of the non-specific monoclonal IgG1 antibody X63, chemically conjugated via a reducible disulfide bridge to the ribosome-inactivating protein saporin, purified from saponaria officinalis. Antibody clone X63 has no known binding ability, and thus can be used as negative control antibody. In combination with saporin, X63-saporin is a useful negative control for targeting IgG1-saporin conjugates such as MC192-saporin.
- Application(s) Negative Control
- Antibody Host Mouse
- Antibody Type Monoclonal
- Specificity No staining has ever been identified with this immunoglobulin demonstrating its non-specific value as a control.
- Species Reactivity Non-Reactive (Negative Control)
- Immunogen Description Unknown, naturally isolated IgG that has no known binding target in mammals
- Conjugate Saporin
- Purity Description Conjugate was purified by ion-exchange chromatography. Purity > 90% by non-reducing SDS-PAGE
- Regulatory Status For research use only.
Product Info
- Product Description X63-saporin is an antibody conjugate comprising of the non-specific monoclonal IgG1 antibody X63, chemically conjugated via a reducible disulfide bridge to the ribosome-inactivating protein saporin, purified from saponaria officinalis. Antibody clone X63 has no known binding ability, and thus can be used as negative control antibody. In combination with saporin, X63-saporin is a useful negative control for targeting IgG1-saporin conjugates such as MC192-saporin.
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- Application(s) Negative Control
- Application Details Negative control for targeting IgG1-saporin conjugates., for instance MC192-saporin. X63-saporin should be used at a concentration equal to that of the test antibody-saporin conjugate.
- Target Isotype control
- Specificity No staining has ever been identified with this immunoglobulin demonstrating its non-specific value as a control.
- Target Host Species Species Independent
- Species Reactivity Non-Reactive (Negative Control)
- Antibody Host Mouse
- Antibody Type Monoclonal
- Antibody Isotype IgG1, kappa
- Clone Name X63
- Conjugate Saporin
- Immunogen Description Unknown, naturally isolated IgG that has no known binding target in mammals
- Biological Activity None. Routinely tested for absence of killing of rat C6 cells in vitro. Note that the primary use of X63-saporin is for in vivo applications.
- Purity Description Conjugate was purified by ion-exchange chromatography. Purity > 90% by non-reducing SDS-PAGE
- Format Lyophilized from a 1 mg/mL solution containing PBS pH 7.2-7.6 without preservative.
- Reconstitution Instructions Spin vial briefly before opening. Reconstitute in sterile-filtered, ultrapure water to achieve a conjugate concentration of 1 mg/mL. Centrifuge to remove any insoluble material. Final buffer contains no preservatives.
- Storage Instructions Lyophilized product is shipped at ambient room temperature. Upon receipt, pulse-centrifuge the vial to collect solid that may be entrapped in the lid. After reconstitution, immediately prepare aliquots and keep the undiluted stock at -80°C for long-term storage. Avoid repeated thaw-freezing. For short-term storage, keep at 2-8°C for up to 2 weeks. it is recommended to handle this product under sterile conditions.
- Storage Temperature 2-8°C (lyophilized); <-70°C (liquid)
- Batch Number Please see item label.
- Expiration Date 12 months after date of receipt (unopened vial).
- Uniprot Number P20656
- Uniprot Number/Name P20656 (RIP6_SAPOF)
- Hazardous Statement Only qualified personnel should handle this product. X63 antibody has no known target receptor, however, standard laboratory protective measures should be followed, including wearing lab coat, gloves and safety glasses. Avoid contact with open wounds and practice good laboratory technique to avoid auto-exposure/auto-injection! Avoid contact of conjugate with reducing agents (eg., DTT, beta-mercaptoethanol) as this will destroy the antibody-saporin conjugate.
- Shipping Temperature 25°C (ambient)
- UNSPSC CODE 41116161
- Regulatory Status For research use only.