Dual specificity tyrosine-phosphorylated-regulated kinase 1A, Mouse Monoclonal Antibody

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Catalog Number
M-829

    Product Info

  • Product Name Dual specificity tyrosine-phosphorylated-regulated kinase 1A, Mouse Monoclonal Antibody
  • Product Description google Mouse anti-Dual specificity tyrosine-phosphorylated-regulated kinase 1A Monoclonal Antibody (Unconjugated), suitable for WB, ELISA.
  • Alternative Names Dual specificity tyrosine-phosphorylation-regulated kinase 1A; MNBH; HP86; Dual specificity YAK1-related kinase; hMNB; DYRK1A
  • Application(s) ELISA, WB
  • Antibody Host Mouse
  • Antibody Type Monoclonal
  • Specificity Specificity has been confirmed by WB and direct ELISA against the antigen. This antibody cross reacts with mouse and rat protein kinase minibrain homolog proteins.
  • Species Reactivity Human, Mouse, Rat
  • Immunogen Description Partial recombinant protein of human protein kinase minibrain homolog (aa 674 to 763) with a GST tag.
  • Conjugate Unconjugated
  • Purity Description Protein G purified immunoglobulin
  • Regulatory Status For research use only.

    Specifications

  • Product Description Mouse anti-Dual specificity tyrosine-phosphorylated-regulated kinase 1A Monoclonal Antibody (Unconjugated), suitable for WB, ELISA.
  • Application(s) ELISA, WB
  • Application Details Direct and sandwich ELISA and WB are recommended for this antibody. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
  • Target Dual specificity tyrosine-phosphorylated-regulated kinase 1A
  • Specificity Specificity has been confirmed by WB and direct ELISA against the antigen. This antibody cross reacts with mouse and rat protein kinase minibrain homolog proteins.
  • Target Host Species Human
  • Species Reactivity Human, Mouse, Rat
  • Antibody Host Mouse
  • Antibody Type Monoclonal
  • Antibody Isotype IgG
  • Clone Name 7D10
  • Conjugate Unconjugated
  • Immunogen Description Partial recombinant protein of human protein kinase minibrain homolog (aa 674 to 763) with a GST tag.
  • Purity Description Protein G purified immunoglobulin
  • Format Lyophilized from PBS pH 7.2
  • Reconstitution Instructions Spin vial briefly before opening. Reconstitute in 100 µL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material.
  • Storage Instructions After reconstitution keep aliquots at -20°C for higher stability or at 2-8°C with an appropriate antibacterial agent. Glycerol (1:1) may be added for additional stability. Avoid repetitive freeze/thaw cycles.
  • Batch Number Please see item label.
  • Expiration Date 12 months after date of receipt (unopened vial).
  • Alternative Names Dual specificity tyrosine-phosphorylation-regulated kinase 1A; MNBH; HP86; Dual specificity YAK1-related kinase; hMNB; DYRK1A
  • Uniprot Number Q13627
  • Uniprot Number/Name Q13627 (DYR1A_HUMAN)
  • Scientific Background
    Protein kinase minibrain homolog phosphorylates serine, threonine and tyrosine residues in its sequence as well as in exogenous substrates. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. There are 5 named isoforms produced by alternative splicing. It is expressed ubiquitously with highest levels in skeletal muscle, testis, fetal lung and kidney, and in the developing central nervous system. It localises to the nucleus speckle. This protein is overexpressed 1.5-fold in fetal Down syndrome brain and considered a strong candidate for learning defects associated with Down syndrome. It belongs to the protein kinase superfamily, CMGC ser/Thr protein kinase family and MNB/DYRK subfamilly.
  • Shipping Temperature 25°C (ambient)
  • UNSPSC CODE 41116161
  • Regulatory Status For research use only.

    Images, Protocols & SDS

  • Western blot analysis on HeLa nuclear extract lysate using mouse monoclonal to human protein kinase minibrain homolog, catalogue number M-829-100.

    Citations & References