SpecificityReacts with ERBB3 / HER3 from Human. This antibody is expected to recognise isoform 1 (NP_001973.2) only.
Species ReactivityBovine (Predicted), Dog (Predicted), Human, Mouse (Predicted), Pig (Predicted), Rat (Predicted)
Immunogen DescriptionA synthetic peptide consisting of amino acids, C-HSRLFPKANAQRT
ConjugateUnconjugated
Purity DescriptionPurified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Application DetailsPeptide ELISA (1:32000), Immunohistochemistry (5 µg/mL), Immunofluorescence (10 µg/mL), Flow Cytometry (10 µg/mL). Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
SpecificityReacts with ERBB3 / HER3 from Human. This antibody is expected to recognise isoform 1 (NP_001973.2) only.
Target Host SpeciesHuman
Species ReactivityBovine (Predicted), Dog (Predicted), Human, Mouse (Predicted), Pig (Predicted), Rat (Predicted)
Antibody HostGoat
Antibody TypePolyclonal
Antibody IsotypeIgG
ConjugateUnconjugated
Immunogen DescriptionA synthetic peptide consisting of amino acids, C-HSRLFPKANAQRT
SequenceHSRLFPKANAQRT
Purity DescriptionPurified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
FormatLiquid antibody. Supplied at 0.5 mg/mL in Tris saline, 0.02% sodium azide, pH 7.3 with 0.5% bovine serum albumin.
Storage InstructionsUpon receipt, aliquot and store at -20°C long-term. Store at 2-8°C short-term (up to 2 weeks). Minimize freezing and thawing.
Batch NumberPlease see item label.
Expiration Date12 months after date of receipt (unopened vial).
Scientific BackgroundTyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. May also be activated by CSPG5. Involved in the regulation of myeloid cell differentiation (Uniprot).