Glial cell line-derived neurotrophic factor (GDNF), Chicken Polyclonal Antibody

As low as US$327.00
Only %1 left
Catalog Number
C-1518

    Product Info

  • Product Name Glial cell line-derived neurotrophic factor (GDNF), Chicken Polyclonal Antibody
  • Product Description google Chicken anti-Glial cell line-derived neurotrophic factor (GDNF) Polyclonal Antibody (Unconjugated), suitable for WB, IHC-Frozen, ICC, ELISA.
  • Alternative Names Glial cell line-derived neurotrophic factor; Astrocyte-derived trophic factor; ATF; GDNF;
  • Application(s) ELISA, ICC, IHC-Frozen, WB
  • Antibody Host Chicken
  • Antibody Type Polyclonal
  • Specificity Human GDNF, cross reactivity to Mouse, Rat
  • Species Reactivity Human, Mouse, Rat
  • Immunogen Description Mixture of two human GDNF peptides (101-118 and 199-211 aa). Both peptides are highly conserved in human and mouse.
  • Conjugate Unconjugated
  • Purity Description Affinity-purified
  • Regulatory Status For research use only.

    Specifications

  • Product Description Chicken anti-Glial cell line-derived neurotrophic factor (GDNF) Polyclonal Antibody (Unconjugated), suitable for WB, IHC-Frozen, ICC, ELISA.
  • Application(s) ELISA, ICC, IHC-Frozen, WB
  • Application Details ELISA, WB and IHC. WB suggested dilution of 1:500-1:2,000. IHC suggested dilution of 1:50-1:500. Biosensis recommends that the optimal working dilution should be determined by the end user.
  • Target Glial cell line-derived neurotrophic factor (GDNF)
  • Specificity Human GDNF, cross reactivity to Mouse, Rat
  • Target Host Species Human
  • Species Reactivity Human, Mouse, Rat
  • Antibody Host Chicken
  • Antibody Type Polyclonal
  • Antibody Isotype IgY
  • Conjugate Unconjugated
  • Immunogen Description Mixture of two human GDNF peptides (101-118 and 199-211 aa). Both peptides are highly conserved in human and mouse.
  • Sequence ENSRGKGRRGQRGKNRGC and ILRKHSAKRCGCI
  • Purity Description Affinity-purified
  • Format Liquid. PBS with 0.02% Sodium Azide
  • Storage Instructions Short term storage at 2-8°C for one week. At -20°C as an undiluted liquid for up to 12 months.
  • Batch Number Please see item label.
  • Expiration Date 12 months after date of receipt (unopened vial).
  • Alternative Names Glial cell line-derived neurotrophic factor; Astrocyte-derived trophic factor; ATF; GDNF;
  • Uniprot Number P39905
  • Uniprot Number/Name P39905 (GDNF_HUMAN)
  • Scientific Background GDNF is a glycosylated, disulfide-bonded homodimer molecule. It was first discovered as a potent survival factor for midbrain dopaminergic neurons and was then shown to rescue these neurons in animal models of Parkinson's disease. GDNF is about 100 times more efficient survival factor for spinal motor neurons than the neurotrophins. FUNCTION: Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. SUBUNIT: Homodimer; disulfide-linked. SUBCELLULAR LOCATION: Secreted protein. ALTERNATIVE PRODUCTS: 2 named isoforms produced by alternative splicing. DISEASE: Defects in GDNF may be a cause of Hirschsprung disease (HSCR). In association with mutations of RET gene, defects in GDNF may be involved in Hirschsprung disease. This genetic disorder of neural crest development is characterized by the absence of intramural ganglion cells in the hindgut, often resulting in intestinal obstruction. DISEASE: Defects in GDNF are a cause of congenital central hypoventilation syndrome (CCHS); also known as congenital failure of autonomic control or Ondine curse. CCHS is a rare disorder characterized by abnormal control of respiration in the absence of neuromuscular or lung disease, or an identifiable brain stem lesion. A deficiency in autonomic control of respiration results in inadequate or negligible ventilatory and arousal responses to hypercapnia and hypoxemia. SIMILARITY: Belongs to the TGF-beta family. GDNF subfamily.
  • Shipping Temperature 2-8°C (on cold packs)
  • UNSPSC CODE 41116161
  • Regulatory Status For research use only.

    Images, Protocols & SDS