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Brain-derived neurotrophic factor (BDNF), Rabbit Polyclonal Antibody
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Catalog Number
R-1004
- Product Name Brain-derived neurotrophic factor (BDNF), Rabbit Polyclonal Antibody
- Product Description Rabbit anti-Brain-derived neurotrophic factor (BDNF) Polyclonal Antibody (Unconjugated), suitable for WB.
- Alternative Names Brain-derived neurotrophic factor; Abrineurin; proBDNF;
- Application(s) WB
- Antibody Host Rabbit
- Antibody Type Polyclonal
- Specificity The specificity of this antibody has been confirmed by WB against the antigen. Human; mouse; rat;
- Species Reactivity Human, Mouse, Rat
- Immunogen Description A peptide (HSDPARRGELSVCDSISEWV) corresponding to a sequence at the N-terminal of human BDNF (amino acids 129-148).
- Conjugate Unconjugated
- Purity Description Affinity purified on antigen column
- Regulatory Status For research use only.
Product Info
- Product Description Rabbit anti-Brain-derived neurotrophic factor (BDNF) Polyclonal Antibody (Unconjugated), suitable for WB.
- Application(s) WB
- Application Details Western Blotting (WB). A concentration of 0.1-0.5 µg/mL is recommended for WB. Human BDNF has a predicted length of 247 residues and MW of 28 kDa for BDNF precursor and 13 kDa for mature BDNF. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
- Target Brain-derived neurotrophic factor (BDNF)
- Specificity The specificity of this antibody has been confirmed by WB against the antigen. Human; mouse; rat;
- Target Host Species Human
- Species Reactivity Human, Mouse, Rat
- Antibody Host Rabbit
- Antibody Type Polyclonal
- Antibody Isotype IgG
- Conjugate Unconjugated
- Immunogen Description A peptide (HSDPARRGELSVCDSISEWV) corresponding to a sequence at the N-terminal of human BDNF (amino acids 129-148).
- Purity Description Affinity purified on antigen column
- Format Lyophilized
- Reconstitution Instructions Spin vial briefly before opening. Reconstitute in 100 µL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material.
- Storage Instructions Maintain lyophilized material at -20°C for up to 12 months after date of receipt. After reconstitution, aliquot and store at -20°C for up to 6 months. Avoid freeze-thaw cycles.
- Batch Number Please see item label.
- Expiration Date 12 months after date of receipt (unopened vial).
- Alternative Names Brain-derived neurotrophic factor; Abrineurin; proBDNF;
- Uniprot Number P23560
- Uniprot Number/Name P23560 (BDNF_HUMAN)
- Scientific Background BDNF belongs to the neurotrophin family and promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it. It is a major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. The alterations in BDNF expression induced by various kinds of brain insult including stress, ischemia, seizure activity and hypoglycaemia, may contribute to some pathologies such as depression, epilepsy, Alzheimer's, and Parkinson's disease. Microglia release BDNF that may contribute to neuroinflammation and neuropathic pain. SUBUNIT: Monomers and homodimers. Binds to NTRK2/TRKB. SUBCELLULAR LOCATION: Secreted protein. Post translation modification: Converted into mature BDNF by plasmin (PLG). SIMILARITY: Belongs to the NGF-beta family.
- Shipping Temperature 25°C (ambient)
- UNSPSC CODE 41116161
- Regulatory Status For research use only.