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Interleukin 1beta (IL-1beta), Rabbit Polyclonal Antibody
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Catalog Number
R-1658
- Product Name Interleukin 1beta (IL-1beta), Rabbit Polyclonal Antibody
- Product Description Rabbit anti-Interleukin 1beta (IL-1beta) Polyclonal Antibody (Unconjugated), suitable for WB.
- Application(s) WB
- Antibody Host Rabbit
- Antibody Type Polyclonal
- Specificity Mouse IL-1beta. Biosensis rabbit polyclonal to mouse IL-1beta has been tested against mouse tissue lysates and reacts well in western blots. Other applications and other species have not yet been tested.
- Species Reactivity Mouse
- Immunogen Description Amino acids 250-265aa, (FLGNNSGQDIIDFTME) from mouse IL-beta protein
- Conjugate Unconjugated
- Purity Description Affinity purified rabbit IgG
- Regulatory Status For research use only.
Product Info
- Product Description Rabbit anti-Interleukin 1beta (IL-1beta) Polyclonal Antibody (Unconjugated), suitable for WB.
- Application(s) WB
- Application Details Western blot 0.5-1.0 µg/mL; detects a band at ~ 17 kDa for the mature mouse form. In some instances the proform at ~30 kDa can also be detected. This antibody does not function for immunohistochemistry.
- Target Interleukin 1beta (IL-1beta)
- Specificity Mouse IL-1beta. Biosensis rabbit polyclonal to mouse IL-1beta has been tested against mouse tissue lysates and reacts well in western blots. Other applications and other species have not yet been tested.
- Target Host Species Mouse
- Species Reactivity Mouse
- Antibody Host Rabbit
- Antibody Type Polyclonal
- Antibody Isotype IgG
- Conjugate Unconjugated
- Immunogen Description Amino acids 250-265aa, (FLGNNSGQDIIDFTME) from mouse IL-beta protein
- Sequence FLGNNSGQDIIDFTME
- Purity Description Affinity purified rabbit IgG
- Format 100ug of affinity purified rabbit IgG in 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg NaN3 buffer.
- Reconstitution Instructions Spin vial briefly before opening. Reconstitute with 200 uL of sterile-filtered, ultrapure water, final concentration 0.5 mg/mL. Centrifuge briefly to remove any insoluble material.
- Storage Instructions At 2-8 degC for one year (lyophilized). After reconstitution aliquot and store frozen at -20degC for up to six months. Avoid repeated freezing and thawing.
- Batch Number Please see item label.
- Expiration Date 12 months after date of receipt (unopened vial).
- Uniprot Number P10749
- Uniprot Number/Name P10749 (IL1B_MOUSE)
- Scientific Background Interleukin-1 beta (IL-1Beta) also know as catabolin, is a cytokine protein that in humans is encoded by the IL1B gene, which localizes to the long arm of chromosome 2. Interleukin 1 was discovered by Gery in 1972. He named it lymphocyte-activating factor (LAF) because it was a lymphocyte mitogen. It was not until 1985 that interleukin 1 was discovered to consist of two distinct proteins, now called interleukin-1 alpha and interleukin-1 beta. IL-1_ is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. Biosensis rabbit polyclonal to mouse IL-1beta has been tested against mouse tissue lysates and reacts well in western blots. Other applications and other species have not yet been tested.
- Shipping Temperature 25°C (ambient)
- UNSPSC CODE 41116161
- Regulatory Status For research use only.