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IL-6 receptor, Rabbit Recombinant Antibody
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Catalog Number
R-2034
- Product Name IL-6 receptor, Rabbit Recombinant Antibody
- Product Description Rabbit anti-IL-6 receptor Recombinant Antibody (Unconjugated), suitable for ELISA, Block.
- Alternative Names IL6R; MRA; atlizumab
- Application(s) Block, ELISA
- Antibody Host Rabbit
- Antibody Type Recombinant
- Specificity Tocilizumab binds specifically to both the membrane bound and soluble forms of human IL-6R. The IL6 receptor is a protein complex consisting of an IL-6 receptor subunit (IL6R) and interleukin 6 signal transducer Glycoprotein 130. Interleukin 6 (IL6) is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in immune response.
- Species Reactivity Human
- Immunogen Description This antibody was prepared by CDR grafting of mouse AUK 12-20 antibody onto a human framework regions.
- Conjugate Unconjugated
- Concentration 1 mg/mL
- Purity Description Purified antibody, via affinity chromatography
- Regulatory Status For research use only.
Product Info
- Product Description Rabbit anti-IL-6 receptor Recombinant Antibody (Unconjugated), suitable for ELISA, Block.
- Application(s) Block, ELISA
- Application Details Tocilizumab can be used in ELISA assays and is able to inhibit the growth of IL-6-dependent tumor cell lines (to the same extent as the original AUK12-20 mouse antibody) - inhibits sIL-6R and mIL-6R-mediated signaling.
- Target IL-6 receptor
- Specificity Tocilizumab binds specifically to both the membrane bound and soluble forms of human IL-6R. The IL6 receptor is a protein complex consisting of an IL-6 receptor subunit (IL6R) and interleukin 6 signal transducer Glycoprotein 130. Interleukin 6 (IL6) is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in immune response.
- Target Host Species Human
- Species Reactivity Human
- Antibody Host Rabbit
- Antibody Type Recombinant
- Antibody Isotype IgG, kappa
- Clone Name rhPM-1 (Tocilizumab)
- Conjugate Unconjugated
- Immunogen Description This antibody was prepared by CDR grafting of mouse AUK 12-20 antibody onto a human framework regions.
- Purity Description Purified antibody, via affinity chromatography
- Format Liquid. PBS with 0.02% Proclin 300.
- Concentration 1 mg/mL
- Storage Instructions Store at 2-8°C for up to 1 month. For longer storage, aliquot and store at -20_C. Avoid mulitiple freeze thaw cycles.
- Batch Number Please see item label.
- Expiration Date Store at 2-8⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C for up to 12 months.
- Alternative Names IL6R; MRA; atlizumab
- Uniprot Number P08887
- Uniprot Number/Name P08887 (IL6RA_HUMAN)
- Scientific Background This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques. Tocilizumab can be used in ELISA assays and is able to inhibit the growth of IL-6-dependent tumor cell lines (to the same extent as the original AUK12-2mouse antibody) - inhibits sIL-6R and mIL-6R-mediated signaling.
- Shipping Temperature 2-8°C (on cold packs)
- UNSPSC CODE 41116161
- Regulatory Status For research use only.
