Dynactin subunit 1, Mouse Monoclonal Antibody

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Catalog Number
M-822

    Product Info

  • Product Name Dynactin subunit 1, Mouse Monoclonal Antibody
  • Product Description google Mouse anti-Dynactin subunit 1 Monoclonal Antibody (Unconjugated), suitable for WB, ELISA.
  • Alternative Names 150 kDa dynein-associated polypeptide; DP-150; DAP-150; p150-glued; p135; DCTN1
  • Application(s) ELISA, WB
  • Antibody Host Mouse
  • Antibody Type Monoclonal
  • Specificity The specificity of this antibody has been confirmed by WB and ELISA against the recombinant protein. No other species have been tested.
  • Species Reactivity Human
  • Immunogen Description Partial sequence recombinant protein of human dynactin subunit 1 (amino acids 1082-1270) with GST tag
  • Conjugate Unconjugated
  • Purity Description Protein G purified immunoglobulin
  • Regulatory Status For research use only.

    Specifications

  • Product Description Mouse anti-Dynactin subunit 1 Monoclonal Antibody (Unconjugated), suitable for WB, ELISA.
  • Application(s) ELISA, WB
  • Application Details This antibody is recommended for WB and direct ELISA. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
  • Target Dynactin subunit 1
  • Specificity The specificity of this antibody has been confirmed by WB and ELISA against the recombinant protein. No other species have been tested.
  • Target Host Species Human
  • Species Reactivity Human
  • Antibody Host Mouse
  • Antibody Type Monoclonal
  • Antibody Isotype IgG
  • Clone Name 1E12
  • Conjugate Unconjugated
  • Immunogen Description Partial sequence recombinant protein of human dynactin subunit 1 (amino acids 1082-1270) with GST tag
  • Purity Description Protein G purified immunoglobulin
  • Format Lyophilized from PBS pH 7.2
  • Reconstitution Instructions Spin vial briefly before opening. Reconstitute in 100 µL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material.
  • Storage Instructions After reconstitution keep aliquots at -20°C for higher stability. Glycerol (1:1) may be added for additional stability. Avoid repetitive freeze/thaw cycles.
  • Batch Number Please see item label.
  • Expiration Date 12 months after date of receipt (unopened vial).
  • Alternative Names 150 kDa dynein-associated polypeptide; DP-150; DAP-150; p150-glued; p135; DCTN1
  • Uniprot Number Q14203
  • Uniprot Number/Name Q14203 (DCTN1_HUMAN)
  • Scientific Background
    Dynactin subunit 1 (DCTN1) is part of a large macromolecular complex of at least 10 components. It is required for cytoplasmic dynein-driven retrograde movement of vesicles and organelles along microtubules. Dynein-dynactin interaction is a key component of the mechanism of axonal transport of vesicles and organelles. Dynactin subunit 1 binds directly to microtubules and to cytoplasmic dynein. It is expressed in the brain and localises to the cytoplasm and the cytoskeleton. It belongs to the dynactin 150 kDa subunit family and contains one CAP-Gly domain. Abnormalities in DCTN1 cause progressive lower motor neuron disease (PLMND).
  • Shipping Temperature 25°C (ambient)
  • UNSPSC CODE 41116161
  • Regulatory Status For research use only.

    Images, Protocols & SDS

  • Western blot detection of GST tagged recombinant protein using mouse monoclonal antibody to human dynactin subunit 1, catalogue number M-822-100. Note, the GST tag alone has a molecular weight of 26 kDa.

    Citations & References