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Neuronal acetylcholine receptor subunit alpha-4, Mouse Monoclonal Antibody
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Catalog Number
M-815
- Product Name Neuronal acetylcholine receptor subunit alpha-4, Mouse Monoclonal Antibody
- Product Description Mouse anti-Neuronal acetylcholine receptor subunit alpha-4 Monoclonal Antibody (Unconjugated), suitable for WB, ELISA.
- Alternative Names CHRNA4
- Application(s) ELISA, WB
- Antibody Host Mouse
- Antibody Type Monoclonal
- Specificity The specificity of this antibody was confirmed by WB and direct ELISA against the antigen. Other species have not been tested.
- Species Reactivity Human
- Immunogen Description This antibody was raised against a partial recombinant protein of human neuronal acetylcholine receptor subunit alpha-4 (amino acids 29 to 128) with a GST tag.
- Conjugate Unconjugated
- Purity Description Protein G purified immunoglobulin
- Regulatory Status For research use only.
Product Info
- Product Description Mouse anti-Neuronal acetylcholine receptor subunit alpha-4 Monoclonal Antibody (Unconjugated), suitable for WB, ELISA.
- Application(s) ELISA, WB
- Application Details This antibody is recommended for WB and direct ELISA. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
- Target Neuronal acetylcholine receptor subunit alpha-4
- Specificity The specificity of this antibody was confirmed by WB and direct ELISA against the antigen. Other species have not been tested.
- Target Host Species Human
- Species Reactivity Human
- Antibody Host Mouse
- Antibody Type Monoclonal
- Antibody Isotype IgG
- Clone Name 4E3
- Conjugate Unconjugated
- Immunogen Description This antibody was raised against a partial recombinant protein of human neuronal acetylcholine receptor subunit alpha-4 (amino acids 29 to 128) with a GST tag.
- Purity Description Protein G purified immunoglobulin
- Format Lyophilized from PBS pH 7.2
- Reconstitution Instructions Spin vial briefly before opening. Reconstitute in 100 µL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material.
- Storage Instructions After reconstitution keep aliquots at -20°C for higher stability or at 2-8°C with an appropriate antibacterial agent. Glycerol (1:1) may be added for additional stability. Avoid repetitive freeze/thaw cycles.
- Batch Number Please see item label.
- Expiration Date 12 months after date of receipt (unopened vial).
- Alternative Names CHRNA4
- Uniprot Number P43681
- Uniprot Number/Name P43681 (ACHA4_HUMAN)
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Scientific Background
Neuronal acetylcholine receptor is composed of alpha and beta subunits. The Alpha-4 subunit can be combined to beta-2 or beta-4 to give rise to functional receptors. Upon binding of acetylcholine, the acetylcholine receptor responds by undergoing an extensive change of conformation affecting all its subunits and lead to the opening of an ion-conducting channel across the plasma membrane. Neuronal acetylcholine receptor subunit alpha-4 is a transmembrane protein that localises to the cell junction, synapse and post synaptic cell membrane. It belongs to the ligand-gated ionic channel family. Abnormalities in the CHRNA4 gene cause autosomal dominant nocturnal frontal lobe epilepsy type 1. This disease is characterised by clusters of motor seizures during sleep.
- Shipping Temperature 25°C (ambient)
- UNSPSC CODE 41116161
- Regulatory Status For research use only.
