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Nicotinic acetylcholine receptor subunit alpha-1, Rabbit Polyclonal Antibody
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Catalog Number
R-1123
- Product Name Nicotinic acetylcholine receptor subunit alpha-1, Rabbit Polyclonal Antibody
- Product Description Rabbit anti-Nicotinic acetylcholine receptor subunit alpha-1 Polyclonal Antibody (Unconjugated), suitable for WB.
- Alternative Names Acetylcholine receptor subunit alpha; CHRNA1; ACHRA; CHNRA;
- Application(s) WB
- Antibody Host Rabbit
- Antibody Type Polyclonal
- Specificity The specificity of this antibody has been confirmed by WB and IHC against the antigen. Human; rat; predicted to react with mouse due to sequence homology;
- Species Reactivity Human, Mouse (Predicted), Rat
- Immunogen Description A synthetic peptide (EHETRLVAKLFKDYS) corresponding to a region (22-36) from the N-terminus of human nicotinic acetylcholine receptor subunit alpha-1.
- Conjugate Unconjugated
- Purity Description Affinity purified on antigen column
- Regulatory Status For research use only.
Product Info
- Product Description Rabbit anti-Nicotinic acetylcholine receptor subunit alpha-1 Polyclonal Antibody (Unconjugated), suitable for WB.
- Application(s) WB
- Application Details Western Blotting (WB). A concentration of 0.1-0.5 µg/mL is recommended for WB. Human acetylcholine receptor subunit alpha-1 (isoform 2) has a predicted length of 482 amino acids and MW of 55 kDa. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
- Target Nicotinic acetylcholine receptor subunit alpha-1
- Specificity The specificity of this antibody has been confirmed by WB and IHC against the antigen. Human; rat; predicted to react with mouse due to sequence homology;
- Target Host Species Human
- Species Reactivity Human, Mouse (Predicted), Rat
- Antibody Host Rabbit
- Antibody Type Polyclonal
- Antibody Isotype IgG
- Conjugate Unconjugated
- Immunogen Description A synthetic peptide (EHETRLVAKLFKDYS) corresponding to a region (22-36) from the N-terminus of human nicotinic acetylcholine receptor subunit alpha-1.
- Purity Description Affinity purified on antigen column
- Format Lyophilized with 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg NaN3
- Reconstitution Instructions Spin vial briefly before opening. Reconstitute in 100 µL sterile-filtered, ultrapure water to achieve an antibody concentration of 1 mg/mL. Centrifuge to remove any insoluble material.
- Storage Instructions At least 12 months after purchase at 2-8°C (lyophilized formulations). After reconstitution, aliquot and store at -20°C for a higher stability. Avoid freeze-thaw cycles.
- Batch Number Please see item label.
- Expiration Date 12 months after date of receipt (unopened vial).
- Alternative Names Acetylcholine receptor subunit alpha; CHRNA1; ACHRA; CHNRA;
- Uniprot Number P02708
- Uniprot Number/Name P02708 (ACHA_HUMAN)
- Scientific Background Upon binding of acetylcholine, the acetylcholine receptor responds by undergoing an extensive change of conformation which affects its alpha and beta subunits and leads to the opening of an ion-conducting channel across the plasma membrane. At least 2 isoforms of the alpha-1 subunit are produced from alternate splicing. Isoform 1 is only expressed in skeletal muscle whereas isoform 2 is constitutively expressed in skeletal muscle, brain, heart, kidney, liver, lung and thymus.
- Shipping Temperature 25°C (ambient)
- UNSPSC CODE 41116161
- Regulatory Status For research use only.