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Tripeptidyl-peptidase 1 (TPP-1), Mouse Monoclonal Antibody
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US$417.00
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Catalog Number
M-802
- Product Name Tripeptidyl-peptidase 1 (TPP-1), Mouse Monoclonal Antibody
- Product Description Mouse anti-Tripeptidyl-peptidase 1 (TPP-1) Monoclonal Antibody (Unconjugated), suitable for WB, IHC-Frozen, ELISA.
- Alternative Names Tripeptidyl-peptidase 1; TPP-l; Tripeptidyl aminopeptidase; Lysosomal pepstatin-insensitive protease; LPIC; Cell growth-inhibiting gene 1 protein; TPP1; CLN2
- Application(s) ELISA, IHC-Frozen, WB
- Antibody Host Mouse
- Antibody Type Monoclonal
- Specificity The specificity of this antibody was confirmed by WB and ELISA against the immunogen. Human. Other species have not been tested.
- Species Reactivity Human
- Immunogen Description Partial recombinant protein of human TPP1 (amino acids 195 to 305) with a GST tag.
- Conjugate Unconjugated
- Purity Description Protein G purified immunoglobulin
- Regulatory Status For research use only.
Product Info
- Product Description Mouse anti-Tripeptidyl-peptidase 1 (TPP-1) Monoclonal Antibody (Unconjugated), suitable for WB, IHC-Frozen, ELISA.
- Application(s) ELISA, IHC-Frozen, WB
- Application Details This antibody is recommended for direct and sandwich ELISA, IHC and WB. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
- Target Tripeptidyl-peptidase 1 (TPP-1)
- Specificity The specificity of this antibody was confirmed by WB and ELISA against the immunogen. Human. Other species have not been tested.
- Target Host Species Human
- Species Reactivity Human
- Antibody Host Mouse
- Antibody Type Monoclonal
- Antibody Isotype IgG
- Clone Name 3B1
- Conjugate Unconjugated
- Immunogen Description Partial recombinant protein of human TPP1 (amino acids 195 to 305) with a GST tag.
- Purity Description Protein G purified immunoglobulin
- Format Lyophilized from PBS, pH 7.6
- Reconstitution Instructions Spin vial briefly before opening. Reconstitute in 100 µL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material.
- Storage Instructions After reconstitution keep aliquots at -20°C for higher stability or at 2-8°C with an appropriate antibacterial agent. Glycerol (1:1) may be added for additional stability. Avoid repetitive freeze/thaw cycles.
- Batch Number Please see item label.
- Expiration Date 12 months after date of receipt (unopened vial).
- Alternative Names Tripeptidyl-peptidase 1; TPP-l; Tripeptidyl aminopeptidase; Lysosomal pepstatin-insensitive protease; LPIC; Cell growth-inhibiting gene 1 protein; TPP1; CLN2
- Uniprot Number O14773
- Uniprot Number/Name O14773 (TPP1_HUMAN)
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Scientific Background
TPP1 is a lysosomal serine protease with tripeptidyl-peptidase I activity. It may act as a non-specific lysosomal peptidase which releases an N-terminal tripeptide from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus. TPP1 is detected in lysosomes and melanosomes in all tissues but it is highest in the heart and placenta. TPP1 is activated by autocatalytic proteolytic processing upon acidification within lysosomes. Defects in TPP1 cause classical late-infantile neuronal ceroid lipofuscinosis (LINCL) which is also known as ceroid lipofuscinosis 2 (CLN2). It is a fatal childhood neurodegenerative disease characterised by progressive visual and mental deterioration, motor disturbance, epilepsy and behavioural changes.
- Shipping Temperature 25°C (ambient)
- UNSPSC CODE 41116161
- Regulatory Status For research use only.
