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Platelet-activating factor acetylhydrolase IB subunit alpha (PAFAH alpha), Mouse Monoclonal Antibody
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Catalog Number
M-855
- Product Name Platelet-activating factor acetylhydrolase IB subunit alpha (PAFAH alpha), Mouse Monoclonal Antibody
- Product Description Mouse anti-Platelet-activating factor acetylhydrolase IB subunit alpha (PAFAH alpha) Monoclonal Antibody (Unconjugated), suitable for WB, ELISA.
- Alternative Names Platelet-activating factor acetylhydrolase IB subunit alpha; PAF acetylhydrolase 45 kDa subunit; PAF-AH 45 kDa subunit; PAF-AH alpha; PAFAH alpha; Lissencephaly-1 protein; LIS-1; PAFAH1B1; LIS1; MDCR; MDS; PAFAHA
- Application(s) ELISA, WB
- Antibody Host Mouse
- Antibody Type Monoclonal
- Specificity Specificity has been confirmed by WB and direct ELISA against the antigen. Human. Other species have not been tested.
- Species Reactivity Human
- Immunogen Description Partial recombinant human PAFAH alpha (1-111) with a GST tag.
- Conjugate Unconjugated
- Purity Description Protein G purified immunoglobulin
- Regulatory Status For research use only.
Product Info
- Product Description Mouse anti-Platelet-activating factor acetylhydrolase IB subunit alpha (PAFAH alpha) Monoclonal Antibody (Unconjugated), suitable for WB, ELISA.
- Application(s) ELISA, WB
- Application Details This antibody is recommended for WB and sandwich ELISA. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
- Target Platelet-activating factor acetylhydrolase IB subunit alpha (PAFAH alpha)
- Specificity Specificity has been confirmed by WB and direct ELISA against the antigen. Human. Other species have not been tested.
- Target Host Species Human
- Species Reactivity Human
- Antibody Host Mouse
- Antibody Type Monoclonal
- Antibody Isotype IgG2a Kappa
- Clone Name 2C12
- Conjugate Unconjugated
- Immunogen Description Partial recombinant human PAFAH alpha (1-111) with a GST tag.
- Purity Description Protein G purified immunoglobulin
- Format Lyophilized from PBS (pH 7.2 - 7.6)
- Reconstitution Instructions Spin vial briefly before opening. Reconstitute in 100 µL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material.
- Storage Instructions After reconstitution keep aliquots at -20°C for higher stability or at 2-8°C with an appropriate antibacterial agent. Glycerol (1:1) may be added for additional stability. Avoid repetitive freeze/thaw cycles.
- Batch Number Please see item label.
- Expiration Date 12 months after date of receipt (unopened vial).
- Alternative Names Platelet-activating factor acetylhydrolase IB subunit alpha; PAF acetylhydrolase 45 kDa subunit; PAF-AH 45 kDa subunit; PAF-AH alpha; PAFAH alpha; Lissencephaly-1 protein; LIS-1; PAFAH1B1; LIS1; MDCR; MDS; PAFAHA
- Uniprot Number P43034
- Uniprot Number/Name P43034 (LIS1_HUMAN)
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Scientific Background
PAFAH alpha encodes the non-catalytic alpha subunit of the intracellular Ib isoform of platelet-activating factor acteylhydrolase, a heterotrimeric enzyme that specifically catalyzes the removal of the acetyl group at the SN-2 position of platelet-activating factor. Two other isoforms of intracellular platelet-activating factor acetylhydrolase exist: one composed of multiple subunits, the other, a single subunit. In addition, a single-subunit isoform of this enzyme is found in serum. It is expressed ubiquitously in both the frontal and occipital areas of the brain. Defects in PAFAH alpha cause lissencephaly type 1 (LIS1) and of subcortical band heterotopia (SBH). Defects in PAFAH alpha are also a cause of Miller-Dieker lissencephaly syndrome (mLDS).
- Shipping Temperature 25°C (ambient)
- UNSPSC CODE 41116161
- Regulatory Status For research use only.
