NGFR/p75 neurotrophin receptor (p75NTR), Rabbit Polyclonal Antibody

As low as US$317.00
Only %1 left
Catalog Number
R-089

    Product Info

  • Product Name NGFR/p75 neurotrophin receptor (p75NTR), Rabbit Polyclonal Antibody
  • Product Description google Rabbit anti-p75 neurotrophin receptor (p75NTR) Polyclonal Antibody (Unconjugated), suitable for IHC-Frozen, ICC.
  • Alternative Names Low-affinity nerve growth factor receptor; NGF receptor; Gp80-LNGFR; p75 ICD; Low affinity neurotrophin receptor p75NTR; CD271 antigen
  • Application(s) ICC, IHC-Frozen
  • Antibody Host Rabbit
  • Antibody Type Polyclonal
  • Specificity IHC shows specific staining for p75NTR. This antibody is known to react to rat p75NTR.
  • Species Reactivity Human, Rat
  • Immunogen Description Extra cellular domain of human p75NTR
  • Conjugate Unconjugated
  • Purity Description Whole serum
  • Regulatory Status For research use only.

    Specifications

  • Product Description Rabbit anti-p75 neurotrophin receptor (p75NTR) Polyclonal Antibody (Unconjugated), suitable for IHC-Frozen, ICC.
  • Application(s) ICC, IHC-Frozen
  • Application Details IHC, immunofluorescence. Recommended to be used at a dilution of 1:500 to 1:2000. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
  • Target NGFR/p75 neurotrophin receptor (p75NTR)
  • Specificity IHC shows specific staining for p75NTR. This antibody is known to react to rat p75NTR.
  • Target Host Species Human
  • Species Reactivity Human, Rat
  • Antibody Host Rabbit
  • Antibody Type Polyclonal
  • Antibody Isotype Mixed
  • Conjugate Unconjugated
  • Immunogen Description Extra cellular domain of human p75NTR
  • Purity Description Whole serum
  • Format Lyophilized
  • Reconstitution Instructions Spin vial briefly before opening. Reconstitute in 100 µL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material.
  • Storage Instructions After reconstitution keep aliquots at -20°C for a higher stability, and at 2-8°C with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.
  • Batch Number Please see item label.
  • Expiration Date 12 months after date of receipt (unopened vial).
  • Alternative Names Low-affinity nerve growth factor receptor; NGF receptor; Gp80-LNGFR; p75 ICD; Low affinity neurotrophin receptor p75NTR; CD271 antigen
  • Uniprot Number P08138
  • Uniprot Number/Name P08138 (TNR16_HUMAN)
  • Scientific Background FUNCTION: Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. SUBUNIT: Homodimer; disulfide-linked. Interacts with p75NTR-associated cell death executor. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1 and NGFRAP1/BEX3. SUBCELLULAR LOCATION: Membrane; single-pass type I membrane protein. DOMAIN: Death domain is responsible for interaction with RANBP9. PTM: N- and O-glycosylated. PTM: O-linked glycans consist of Gal(1-3)GalNAc core elongated by 1 or 2 NeuNAc. PTM: Phosphorylated on serine residues. SIMILARITY: Contains 1 death domain. SIMILARITY: Contains 4 TNFR-Cys repeats.
  • Shipping Temperature 25°C (ambient)
  • UNSPSC CODE 41116161
  • Regulatory Status For research use only.

    Images, Protocols & SDS

  • IHC on rat spinal cord (free floating cryo section) using Rabbit antibody to recombinant human p75NTR: whole serum (R-089-100) at a dilution of 1: 1000.

  • IHC on rat trigeminal nerve (free floating cryo section) using Rabbit antibody to recombinant human p75NTR: whole serum (R-089-100) at a dilution of 1: 1000.

    Citations & References