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Mesencephalic astrocyte-derived neurotrophic factor (MANF), Mouse Monoclonal Antibody
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Catalog Number
M-1673
- Product Name Mesencephalic astrocyte-derived neurotrophic factor (MANF), Mouse Monoclonal Antibody
- Product Description Mouse anti-Mesencephalic astrocyte-derived neurotrophic factor (MANF) Monoclonal Antibody (Unconjugated), suitable for WB.
- Alternative Names ARMET, ARP
- Application(s) WB
- Antibody Host Mouse
- Antibody Type Monoclonal
- Specificity MANF (Mesencephalic astrocyte-derived neurotrophic factor).
- Species Reactivity Human
- Immunogen Description Recombinant human MANF protein produced using CHO-based cell line. Immunogen is purified from cell culture supernatant.
- Conjugate Unconjugated
- Purity Description Purified with Protein G affinity chromatography
- Regulatory Status For research use only.
Product Info
- Product Description Mouse anti-Mesencephalic astrocyte-derived neurotrophic factor (MANF) Monoclonal Antibody (Unconjugated), suitable for WB.
- Application(s) WB
- Application Details Western blot (WB) at a suggested concentration of 0.5-2.0 µg/mL, Immunofluorescence 1-10 µg/mL and indirect ELISA 0.1-0.2 µg/mL. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
- Target Mesencephalic astrocyte-derived neurotrophic factor (MANF)
- Specificity MANF (Mesencephalic astrocyte-derived neurotrophic factor).
- Target Host Species Human
- Species Reactivity Human
- Antibody Host Mouse
- Antibody Type Monoclonal
- Antibody Isotype IgG1
- Conjugate Unconjugated
- Immunogen Description Recombinant human MANF protein produced using CHO-based cell line. Immunogen is purified from cell culture supernatant.
- Purity Description Purified with Protein G affinity chromatography
- Format PBS pH 7.4, with 0.1% sodium azide.
- Storage Instructions Store at -20°C or -70°C upon receipt. After opening maintain undiluted in smaller aliquots at -20°C or -70°C for up to 6 months. Avoid multiple freeze-thaw cycles.
- Batch Number Please see item label.
- Expiration Date 12 months after date of receipt (unopened vial).
- Alternative Names ARMET, ARP
- Uniprot Number P55145
- Uniprot Number/Name P55145 (MANF_HUMAN)
- Scientific Background MANF is a trophic factor for midbrain dopamine neurons in vivo. It prevents the 6-OHDA- induced degeneration of dopamine neurons in rodent models of Parkinson's disease (Lindholm et al., 2008, Voutilainen et al., 2009). When administered after 6-OHDA-lesioning it restores the dopaminergic function and prevents degeneration of dopamine neurons in substantia nigra pars compacta.
- Shipping Temperature 25°C (ambient)
- UNSPSC CODE 41116161
- Regulatory Status For research use only.
