Neurturin (NTN, Mouse Monoclonal Antibody

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Catalog Number
M-1670

    Product Info

  • Product Name Neurturin (NTN, Mouse Monoclonal Antibody
  • Product Description google Mouse anti-Neurturin Monoclonal Antibody (Unconjugated), suitable for WB.
  • Application(s) WB
  • Antibody Host Mouse
  • Antibody Type Monoclonal
  • Specificity Human NTN (Neurturin)
  • Species Reactivity Human
  • Immunogen Description Recombinant human NRTN protein produced using CHO-based suspension cell line. Protein was purified from the cell culture supernatant.
  • Conjugate Unconjugated
  • Purity Description Protein G purified IgG
  • Regulatory Status For research use only.

    Specifications

  • Product Description Mouse anti-Neurturin Monoclonal Antibody (Unconjugated), suitable for WB.
  • Application(s) WB
  • Application Details Western blot (WB) at a suggested dilution of 1:5,000-1:10,000. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
  • Target Neurturin
  • Specificity Human NTN (Neurturin)
  • Target Host Species Human
  • Species Reactivity Human
  • Antibody Host Mouse
  • Antibody Type Monoclonal
  • Antibody Isotype IgG1
  • Clone Name 1B11
  • Conjugate Unconjugated
  • Immunogen Description Recombinant human NRTN protein produced using CHO-based suspension cell line. Protein was purified from the cell culture supernatant.
  • Purity Description Protein G purified IgG
  • Format PBS pH 7.4, with 0.1% sodium azide
  • Storage Instructions Store at -20°C or -70°C upon receipt. After opening divide antibody into smaller aliquots and store at -20°C or -70°C for up to six months. Avoid multiple freeze-thaw cycles as product degradation may result.
  • Batch Number Please see item label.
  • Expiration Date 12 months after date of receipt (unopened vial).
  • Uniprot Number Q99748
  • Uniprot Number/Name Q99748 (NRTN_HUMAN)
  • Scientific Background Neurturin (NTN) is a member of the GDNF family of neurotrophic factors. This protein is a potent survival factor for several populations of central and peripheral neurons in mature and developing rodents. FUNCTION: Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells. SUBUNIT: Homodimer; disulfide-linked. SUBCELLULAR LOCATION: Secreted protein. DISEASE: Defects in NRTN are a cause of Hirschsprung disease (HSCR). In association with mutations of RET gene, and possibly with other loci, defects in NRTN are involved in Hirschsprung disease. This genetic disorder of neural crest development is characterized by the absence of intramural ganglion cells in the hindgut, often resulting in intestinal obstruction. SIMILARITY: Belongs to the TGF-beta family. GDNF subfamily.
  • Shipping Temperature 25°C (ambient)
  • UNSPSC CODE 41116161
  • Regulatory Status For research use only.

    Images, Protocols & SDS

  • Western-Blot detection of human NRTN expressed in CHO cells. Line 1. hNRTN-containing CHOEBNALT85 cell culture supernatant. Line 2. Negative control - CHOEBNALT85 cell culture supernatant. 5 µl of supernatant were loaded per line. Primary antibody dilution 1:5000 was used. Antibody recognizes protein dimeric, and monomeric variants.

    Citations & References