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Neurturin (NTN), Rabbit Polyclonal Antibody
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Catalog Number
R-1669
- Product Name Neurturin (NTN), Rabbit Polyclonal Antibody
- Product Description Rabbit anti-Neurturin (NTN) Polyclonal Antibody (Unconjugated), suitable for WB.
- Application(s) WB
- Antibody Host Rabbit
- Antibody Type Polyclonal
- Specificity Antibody does not show cross-reactivity to other GDNF-family proteins.
- Species Reactivity Human
- Immunogen Description Recombinant human NRTN protein produced using CHO-based suspension cell line. Protein was purified from the cell culture supernatant.
- Conjugate Unconjugated
- Purity Description Protein G purified IgG
- Regulatory Status For research use only.
Product Info
- Product Description Rabbit anti-Neurturin (NTN) Polyclonal Antibody (Unconjugated), suitable for WB.
- Application(s) WB
- Application Details Western blot (WB) at a suggested dilution of 1:500-1:1,000. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
- Target Neurturin (NTN)
- Specificity Antibody does not show cross-reactivity to other GDNF-family proteins.
- Target Host Species Human
- Species Reactivity Human
- Antibody Host Rabbit
- Antibody Type Polyclonal
- Antibody Isotype IgG
- Conjugate Unconjugated
- Immunogen Description Recombinant human NRTN protein produced using CHO-based suspension cell line. Protein was purified from the cell culture supernatant.
- Purity Description Protein G purified IgG
- Format Concentrated ammonium sulphate in PBS pH 7.4.
- Storage Instructions Store at 2-8°C upon receipt. As product is (NH4)2SO4 (ammonium sulfate) precipitate, mix well by pipetting or vortexing prior to use.
- Batch Number Please see item label.
- Expiration Date 12 months after date of receipt (unopened vial).
- Uniprot Number Q99748
- Uniprot Number/Name Q99748 (NRTN_HUMAN)
- Scientific Background Neurturin (NTN) is a member of the GDNF family of neurotrophic factors. This protein is a potent survival factor for several populations of central and peripheral neurons in mature and developing rodents. FUNCTION: Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells. SUBUNIT: Homodimer; disulfide-linked. SUBCELLULAR LOCATION: Secreted protein. DISEASE: Defects in NRTN are a cause of Hirschsprung disease (HSCR). In association with mutations of RET gene, and possibly with other loci, defects in NRTN are involved in Hirschsprung disease. This genetic disorder of neural crest development is characterized by the absence of intramural ganglion cells in the hindgut, often resulting in intestinal obstruction. SIMILARITY: Belongs to the TGF-beta family. GDNF subfamily.
- Shipping Temperature 2-8°C (on cold packs)
- UNSPSC CODE 41116161
- Regulatory Status For research use only.
