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Cytochrome P450 46A1, Mouse Monoclonal Antibody
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Catalog Number
M-821
- Product Name Cytochrome P450 46A1, Mouse Monoclonal Antibody
- Product Description Mouse anti-Cytochrome P450 46A1 Monoclonal Antibody (Unconjugated), suitable for WB, ELISA.
- Alternative Names Cholesterol 24-hydroxylase; CH24H; CYP46A1; CYP46
- Application(s) ELISA, WB
- Antibody Host Mouse
- Antibody Type Monoclonal
- Specificity The specificity of this antibody has been confirmed by WB and ELISA against the antigen. Other species have not yet been tested.
- Species Reactivity Human
- Immunogen Description Partial recombinant protein of human cytochrome P450 46A1 (amino acids 201 to 300) with a GST tag.
- Conjugate Unconjugated
- Purity Description Protein G purified immunoglobulin
- Regulatory Status For research use only.
Product Info
- Product Description Mouse anti-Cytochrome P450 46A1 Monoclonal Antibody (Unconjugated), suitable for WB, ELISA.
- Application(s) ELISA, WB
- Application Details This antibody is recommended for WB and direct and sandwich ELISA. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
- Target Cytochrome P450 46A1
- Specificity The specificity of this antibody has been confirmed by WB and ELISA against the antigen. Other species have not yet been tested.
- Target Host Species Human
- Species Reactivity Human
- Antibody Host Mouse
- Antibody Type Monoclonal
- Antibody Isotype IgG
- Clone Name 1A11
- Conjugate Unconjugated
- Immunogen Description Partial recombinant protein of human cytochrome P450 46A1 (amino acids 201 to 300) with a GST tag.
- Purity Description Protein G purified immunoglobulin
- Format Lyophilized from PBS pH 7.2
- Reconstitution Instructions Spin vial briefly before opening. Reconstitute in 100 µL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material.
- Storage Instructions After reconstitution keep aliquots at -20°C for higher stability or at 2-8°C with an appropriate antibacterial agent. Glycerol (1:1) may be added for additional stability. Avoid repetitive freeze/thaw cycles.
- Batch Number Please see item label.
- Expiration Date 12 months after date of receipt (unopened vial).
- Alternative Names Cholesterol 24-hydroxylase; CH24H; CYP46A1; CYP46
- Uniprot Number Q9Y6A2
- Uniprot Number/Name Q9Y6A2 (CP46A_HUMAN)
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Scientific Background
Cytochrome P450 46A1 belongs to the cytochrome P450 family which are a group of monooxygenases. Cytochrome P450 46A1 is involved in the turnover of cholesterol converting it into 24S-hydroxycholesterol and, to a lesser extent, 25-hydroxycholesterol. This protein is expressed in the brain and mRNA has been found to be broadly distributed with higher levels in the gray matter zones and lower levels in white matter areas. It is not detected in fetal brain but its expression increases linearly with age. It localises to the endoplasmic reticulum membrane and the microsome membrane. The unprocessed precursor is 500 amino acids long and has a predicted molecular weight of 56.8KDa.
- Shipping Temperature 25°C (ambient)
- UNSPSC CODE 41116161
- Regulatory Status For research use only.
