Huntingtin-associated protein 1 (HAP-1), Rabbit Polyclonal Antibody

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Catalog Number
R-090

    Product Info

  • Product Name Huntingtin-associated protein 1 (HAP-1), Rabbit Polyclonal Antibody
  • Product Description google Rabbit anti-Huntingtin-associated protein 1 (HAP-1) Polyclonal Antibody (Unconjugated), suitable for IHC-Frozen.
  • Alternative Names Huntingtin-associated protein 1; HAP1
  • Application(s) IHC-Frozen
  • Antibody Host Rabbit
  • Antibody Type Polyclonal
  • Specificity Specificity for HAP-1 was confirmed by IHC. This antiserum is known to react with rat HAP-1. Other species have not yet been tested.
  • Species Reactivity Rat
  • Immunogen Description Recombinant rat HAP-1
  • Conjugate Unconjugated
  • Purity Description Whole serum
  • Regulatory Status For research use only.

    Specifications

  • Product Description Rabbit anti-Huntingtin-associated protein 1 (HAP-1) Polyclonal Antibody (Unconjugated), suitable for IHC-Frozen.
  • Application(s) IHC-Frozen
  • Application Details IHC. A dilution of 1:500 to 1:3000 is recommended for this application. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
  • Target Huntingtin-associated protein 1 (HAP-1)
  • Specificity Specificity for HAP-1 was confirmed by IHC. This antiserum is known to react with rat HAP-1. Other species have not yet been tested.
  • Target Host Species Rat
  • Species Reactivity Rat
  • Antibody Host Rabbit
  • Antibody Type Polyclonal
  • Antibody Isotype Mixed
  • Conjugate Unconjugated
  • Immunogen Description Recombinant rat HAP-1
  • Purity Description Whole serum
  • Format Lyophilized
  • Reconstitution Instructions Spin vial briefly before opening. Reconstitute in 100 µL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material.
  • Storage Instructions After reconstitution keep aliquots at -20°C for a higher stability, and at 2-8°C with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.
  • Batch Number Please see item label.
  • Expiration Date 12 months after date of receipt (unopened vial).
  • Alternative Names Huntingtin-associated protein 1; HAP1
  • Uniprot Number P54256
  • Uniprot Number/Name P54256 (HAP1_RAT)
  • Scientific Background FUNCTION: Associates specifically with huntingtin. This binding is enhanced by an expanded polyglutamine repeat. ALTERNATIVE PRODUCTS: 2 named isoforms produced by alternative splicing. TISSUE SPECIFICITY: In the brain, especially in the olfactory bulb and in the brain stem. No detectable expression in peripheral tissues such as lung, testis, spleen, and small intestine. SIMILARITY: Contains 1 HAP1 N-terminal domain.
  • Shipping Temperature 25°C (ambient)
  • UNSPSC CODE 41116161
  • Regulatory Status For research use only.

    Images, Protocols & SDS

  • IHC on rat DRG (free floating cryo section) using Rabbit antibody to recombinant rat HAP-1: whole serum (R-090-100) at a dilution of 1: 1000.

  • IHC on rat spinal cord (free floating cryo section) using Rabbit antibody to recombinant rat HAP-1: whole serum (R-090-100) at a dilution of 1: 1000. Motor neurons are intensely stained.

    Citations & References

  • General References Zhou, H. et al. (2003). J. Cell Biol. 163(1): 109-11
    Fusco, F.R. et al. (2003). Eur. J. Neurosci. 18: 1-
    Pardo, R. et al. (2006). J. Neurosci. 26(5): 1635-164
    Harper, S. Q. et al. (2005). Proc. Nat. Acad. Sci. (USA) 102: 5820-582
    Qin, Z. et al. (2004). J. Neurosci. 24(1): 269-28
    Tang, T. S. et al. (2003). Neuron 39(2): 227-23