Sodium channel protein type 8 subunit alpha, Mouse Monoclonal Antibody

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Catalog Number
M-864

    Product Info

  • Product Name Sodium channel protein type 8 subunit alpha, Mouse Monoclonal Antibody
  • Product Description google Mouse anti-Sodium channel protein type 8 subunit alpha Monoclonal Antibody (Unconjugated), suitable for WB, ELISA.
  • Alternative Names Sodium channel protein type VIII subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.6; SCN8A; MED
  • Application(s) ELISA, WB
  • Antibody Host Mouse
  • Antibody Type Monoclonal
  • Specificity Specificity has been confirmed by WB and direct ELISA against the antigen. Human, mouse and rat. Other species have not been tested.
  • Species Reactivity Human, Mouse, Rat
  • Immunogen Description Partial recombinant human Sodium channel protein type 8 subunit alpha (amino acids 1854-1951) with a GST tag.
  • Conjugate Unconjugated
  • Purity Description Protein G purified immunoglobulin
  • Regulatory Status For research use only.

    Specifications

  • Product Description Mouse anti-Sodium channel protein type 8 subunit alpha Monoclonal Antibody (Unconjugated), suitable for WB, ELISA.
  • Application(s) ELISA, WB
  • Application Details This antibody is recommended for WB, immunofluorescence and direct ELISA. The recommended dilution for this antibody is 10 µg/mL for immunofluorescence. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
  • Target Sodium channel protein type 8 subunit alpha
  • Specificity Specificity has been confirmed by WB and direct ELISA against the antigen. Human, mouse and rat. Other species have not been tested.
  • Target Host Species Human
  • Species Reactivity Human, Mouse, Rat
  • Antibody Host Mouse
  • Antibody Type Monoclonal
  • Antibody Isotype IgG
  • Clone Name 4G7
  • Conjugate Unconjugated
  • Immunogen Description Partial recombinant human Sodium channel protein type 8 subunit alpha (amino acids 1854-1951) with a GST tag.
  • Purity Description Protein G purified immunoglobulin
  • Format Lyophilized from PBS pH 7.2
  • Reconstitution Instructions Spin vial briefly before opening. Reconstitute in 100 µL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material.
  • Storage Instructions After reconstitution keep aliquots at -20°C for higher stability or at 2-8°C with an appropriate antibacterial agent. Glycerol (1:1) may be added for additional stability. Avoid repetitive freeze/thaw cycles.
  • Batch Number Please see item label.
  • Expiration Date 12 months after date of receipt (unopened vial).
  • Alternative Names Sodium channel protein type VIII subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.6; SCN8A; MED
  • Uniprot Number Q9UQD0
  • Uniprot Number/Name Q9UQD0 (SCN8A_HUMAN)
  • Scientific Background
    Sodium channel protein type 8 subunit alpha mediates the voltage-dependent sodium ion permeability of excitable membranes. Adopting opened or closed conformation in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na ions may pass in accordance with their electrochemical gradient. It is a multi-pass transmembrane protein that is widely expressed in neurons of the central and peripheral nervous system. There are four named isoforms. The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1, S2, S3, S5, S6) and one positively charged segment, S4. Segments S4 are thought to be the voltage-sensors and are characterised by a series of positively charged amino acids at every third position.
  • Shipping Temperature 25°C (ambient)
  • UNSPSC CODE 41116161
  • Regulatory Status For research use only.

    Images, Protocols & SDS

  • Immunofluorescent detection of Sodium channel protein type 8 subunit alpha expression in mouse NIH/ Swiss embryo cell lysate. The anti-Sodium channel protein type 8 subunit alpha primary antibody, catalogue number M-864-100, was used at a concentration of 10 µg/mL.

    Citations & References