Product DescriptionMouse anti-Small conductance calcium-activated potassium channel protein 3 (KCNN3) Polyclonal Antibody (Unconjugated), suitable for WB, ELISA.
Application(s)ELISA, WB
Application DetailsThis antibody is recommended for WB and ELISA. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
TargetSmall conductance calcium-activated potassium channel protein 3 (KCNN3)
SpecificitySpecificity has been confirmed by WB and direct ELISA against the antigen. Human. Other species have not been tested.
Target Host SpeciesHuman
Species ReactivityHuman
Antibody HostMouse
Antibody TypePolyclonal
Antibody IsotypeMixed
ConjugateUnconjugated
Immunogen DescriptionPartial recombinant human KCNN3 (301-410) with a GST tag.
Purity DescriptionWhole serum
FormatLiquid. 50% glycerol
Storage InstructionsKeep aliquots at -20°C for higher stability or at 2-8°C with an appropriate antibacterial agent. Avoid repetitive freeze/thaw cycles.
Batch NumberPlease see item label.
Expiration Date12 months after date of receipt (unopened vial).
Alternative NamesSmall conductance calcium-activated potassium channel; Potassium intermediate/small conductance calcium-activated channel subfamily N member 3 isoform CRAβd; Potassium intermediate/small conductance calcium-activated channel subfamily N member 3
KCNN3 forms one of several calcium-activated potassium channels which are activated in a voltage-independent manner and have a relatively small unit conductance and high sensitivity to intracellular calcium. Activation is followed by membrane hyperpolarization. It is thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin. KCCN3 contains an intracellular N and C terminus and 6 highly conserved transmembrane segments. It exists as a heterooligomer composed of 4 channel subunits each of which binds to a calmodulin subunit which regulates the channel activity through calcium-binding. These channels are thought to be potential therapeutic targets for disorders such as sleep apnea or sudden infant death syndrome and for regulating uterine contractions during labor. It was also suggested that KCNN3 may contribute to age-dependent decline in learning and memory and synaptic plasticity. Also it is thought that KCNN3 channel expression in endothelial cells may be a fundamental determinant of vascular tone and blood pressure.