Small conductance calcium-activated potassium channel protein 3 (KCNN3), Mouse Polyclonal Antibody

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Catalog Number
Mo-931

    Product Info

  • Product Name Small conductance calcium-activated potassium channel protein 3 (KCNN3), Mouse Polyclonal Antibody
  • Product Description google Mouse anti-Small conductance calcium-activated potassium channel protein 3 (KCNN3) Polyclonal Antibody (Unconjugated), suitable for WB, ELISA.
  • Alternative Names Small conductance calcium-activated potassium channel; Potassium intermediate/small conductance calcium-activated channel subfamily N member 3 isoform CRAβd; Potassium intermediate/small conductance calcium-activated channel subfamily N member 3
  • Application(s) ELISA, WB
  • Antibody Host Mouse
  • Antibody Type Polyclonal
  • Specificity Specificity has been confirmed by WB and direct ELISA against the antigen. Human. Other species have not been tested.
  • Species Reactivity Human
  • Immunogen Description Partial recombinant human KCNN3 (301-410) with a GST tag.
  • Conjugate Unconjugated
  • Purity Description Whole serum
  • Regulatory Status For research use only.

    Specifications

  • Product Description Mouse anti-Small conductance calcium-activated potassium channel protein 3 (KCNN3) Polyclonal Antibody (Unconjugated), suitable for WB, ELISA.
  • Application(s) ELISA, WB
  • Application Details This antibody is recommended for WB and ELISA. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
  • Target Small conductance calcium-activated potassium channel protein 3 (KCNN3)
  • Specificity Specificity has been confirmed by WB and direct ELISA against the antigen. Human. Other species have not been tested.
  • Target Host Species Human
  • Species Reactivity Human
  • Antibody Host Mouse
  • Antibody Type Polyclonal
  • Antibody Isotype Mixed
  • Conjugate Unconjugated
  • Immunogen Description Partial recombinant human KCNN3 (301-410) with a GST tag.
  • Purity Description Whole serum
  • Format Liquid. 50% glycerol
  • Storage Instructions Keep aliquots at -20°C for higher stability or at 2-8°C with an appropriate antibacterial agent. Avoid repetitive freeze/thaw cycles.
  • Batch Number Please see item label.
  • Expiration Date 12 months after date of receipt (unopened vial).
  • Alternative Names Small conductance calcium-activated potassium channel; Potassium intermediate/small conductance calcium-activated channel subfamily N member 3 isoform CRAβd; Potassium intermediate/small conductance calcium-activated channel subfamily N member 3
  • Uniprot Number Q9UGI6
  • Uniprot Number/Name Q9UGI6 (KCNN3_HUMAN)
  • Scientific Background
    KCNN3 forms one of several calcium-activated potassium channels which are activated in a voltage-independent manner and have a relatively small unit conductance and high sensitivity to intracellular calcium. Activation is followed by membrane hyperpolarization. It is thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin. KCCN3 contains an intracellular N and C terminus and 6 highly conserved transmembrane segments. It exists as a heterooligomer composed of 4 channel subunits each of which binds to a calmodulin subunit which regulates the channel activity through calcium-binding. These channels are thought to be potential therapeutic targets for disorders such as sleep apnea or sudden infant death syndrome and for regulating uterine contractions during labor. It was also suggested that KCNN3 may contribute to age-dependent decline in learning and memory and synaptic plasticity. Also it is thought that KCNN3 channel expression in endothelial cells may be a fundamental determinant of vascular tone and blood pressure.
  • Shipping Temperature 2-8°C (on cold packs)
  • UNSPSC CODE 41116161
  • Regulatory Status For research use only.

    Images, Protocols & SDS

  • Western blot detection of KCNN3 expression in human retinoblastoma whole cell lysate.

    Citations & References