Product DescriptionRabbit anti-Connexin-26 (Cx26) Polyclonal Antibody (Unconjugated), suitable for WB.
Application DetailsWestern Blotting (WB). A concentration of 1.0-2.0 µg/mL is recommended for WB. The predicted length of rat Connexin-26 is 226 residues and MW of 26 kDa. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
SpecificityThe specificity of this antibody has been confirmed by WB against the antigen. Human; mouse; rat; rabbit;
Target Host SpeciesRat
Species ReactivityHuman, Mouse, Rabbit, Rat
Immunogen DescriptionA synthetic peptide (CYLFIRYCSGKSKRPV) corresponding to the amino acid sequence 211-226 from rat Connexin-26.
Purity DescriptionAffinity purified on antigen column
Scientific BackgroundA gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexins, through which materials of low molecular weight diffuse from one cell to a neighbouring cell. Each connexin is composed of a hexamer of connexin proteins. Connexins are a multi-gene family of highly related proteins. At least a dozen distinct connexin genes have been identified and many are expressed in a tissue-specific manner. Two distinct lineages, class I (beta) and class II (alpha), have been identified in mammals. Connexin-26 belongs to the class 1 (beta) group of connexins. Mutations in Connexin-26 are associated with genetically derived hearing impairments, including autosomal recessive non syndromic deafness.