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SARS-CoV-2 membrane protein, Rabbit Polyclonal Antibody
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Catalog Number
R-1957
- Product Name SARS-CoV-2 membrane protein, Rabbit Polyclonal Antibody
- Product Description Rabbit anti-SARS-CoV-2 membrane protein Polyclonal Antibody (Unconjugated), suitable for ELISA.
- Alternative Names SARS-CoV-2/SARS-CoV Matrix Antibody: Membrane protein, E1 glycoprotein, M protein
- Application(s) ELISA
- Antibody Host Rabbit
- Antibody Type Polyclonal
- Specificity Predicted reactivity based on immunogen sequence: SARS-CoV-2/SARS-CoV2 Matrix protein: (identity 80%, homology 93%)
- Species Reactivity Virus
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Immunogen Description
Anti-SARS-CoV-2/SARS-CoV Matrix antibody (R-1957-100) was raised against a peptide corresponding to 15 amino acids near the carboxy-terminus of SARS-CoV-2/SARS-CoV Matrix protein.
The immunogen is located within the last 50 amino acids of SARS-CoV-2/SARS-CoV Matrix. - Conjugate Unconjugated
- Concentration 1 mg/mL
- Purity Description Affinity-purified via peptide column.
- Regulatory Status For research use only.
Product Info
- Product Description Rabbit anti-SARS-CoV-2 membrane protein Polyclonal Antibody (Unconjugated), suitable for ELISA.
- Application(s) ELISA
- Application Details SARS-CoV-2/SARS-CoV Matrix antibody can be used for the detection of SARS-CoV-2/SARS-CoV Matrix protein in ELISA. It will detect 5 ng of free peptide at 1 μg/mL.
- Target SARS-CoV-2 membrane protein
- Specificity Predicted reactivity based on immunogen sequence: SARS-CoV-2/SARS-CoV2 Matrix protein: (identity 80%, homology 93%)
- Target Host Species Virus
- Species Reactivity Virus
- Antibody Host Rabbit
- Antibody Type Polyclonal
- Antibody Isotype IgG
- Conjugate Unconjugated
-
Immunogen Description
Anti-SARS-CoV-2/SARS-CoV Matrix antibody (R-1957-100) was raised against a peptide corresponding to 15 amino acids near the carboxy-terminus of SARS-CoV-2/SARS-CoV Matrix protein.
The immunogen is located within the last 50 amino acids of SARS-CoV-2/SARS-CoV Matrix. - Homology Predicted reactivity based on immunogen sequence: SARS-CoV-2/SARS-CoV2 Matrix protein: (identity 80%, homology 93%)
- Isoform Information SARS-CoV-2/SARS-CoV Matrix has one isoform (222aa).
- Purity Description Affinity-purified via peptide column.
- Format Liquid. SARS-CoV-2/SARS-CoV Matrix Antibody is supplied in PBS containing 0.02% sodium azide. Conc.1 mg/mL
- Concentration 1 mg/mL
- Reconstitution Instructions Spin vial briefly before opening.
- Storage Instructions SARS-CoV-2/SARS-CoV Matrix antibody can be stored at 2-8°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
- Batch Number Please see item label.
- Expiration Date 12 months after date of receipt (unopened vial).
- Alternative Names SARS-CoV-2/SARS-CoV Matrix Antibody: Membrane protein, E1 glycoprotein, M protein
- Uniprot Number P59596
- Uniprot Number/Name P59596 (VME1_SARS)
- NCBI Official Full Name Membrane protein
- NCBI Official Symbol M
- NCBI Organism SARS coronavirus
- Scientific Background Coronavirus disease 2019 (COVID-19), formerly known as 2019-nCoV acute respiratory disease, is an infectious disease caused by SARS-CoV-2/SARS-CoV-2, a virus closely related to the SARS virus (1). The disease is the cause of the 2019–20 coronavirus outbreak (2). The structure of 2019-nCoV consists of the following: a spike protein (S), hemagglutinin-esterease dimer (HE), a membrane glycoprotein (M), an envelope protein (E) a nucleoclapid protein (N) and RNA. The membrane (M) protein or matrix protein is the most abundant structural protein and defines the shape of the viral envelope (3). It is an integral membrane protein involved in the budding of the viral particles and interacts with S (Spike) protein. It involves in organization of the nucleoprotein inside, which includes many copies of the N (nucleocapsid) protein bound to the genomic RNA. The M protein holds dominant cellular immunogenicity and has been determined as a protective antigen in humoral responses, which suggests it would serve as a potential target in vaccine design (4).
- Research Area Infectious Disease
- Shipping Temperature 2-8°C (on cold packs)
- UNSPSC CODE 41116161
- Regulatory Status For research use only.
Specifications
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General References
Gorbalenya. bioRxiv: 2020.
Hui et al. Int J Infect Dis. 2020;91:264-266.
Neuman, et al. J Struct Biol. 2011;174(1):11–22.
Liu et al. J Infect Dis. 2010;202(8):1171-80.