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Integrin alpha-5, Human Recombinant Antibody
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Catalog Number
H-1971
Discontinued
- Product Name Integrin alpha-5, Human Recombinant Antibody
- Product Description Human anti-Integrin alpha-5 Recombinant Antibody (Unconjugated), suitable for ELISA, FC, ICC, Block, IHC.
- Alternative Names Fibronectin receptor; CD49 antigen-like family member E; Integrin alpha-F; VLA-5; CD49e.
- Application(s) Block, ELISA, FC, ICC, IHC
- Antibody Host Human
- Antibody Type Recombinant
- Specificity The antibody binds to human α5β1 integrin with a Kd of 0.367 nM (determined by Biacore), an EC50 of 0.2 nM and an IC50 of 2.3 nM.
- Species Reactivity Human
- Immunogen Description Heterodimeric α5β1Fc fusion protein
- Conjugate Unconjugated
- Concentration 1 mg/mL
- Purity Description Purified antibody, via affinity chromatography
- Regulatory Status For research use only.
Product Info
- Product Description Human anti-Integrin alpha-5 Recombinant Antibody (Unconjugated), suitable for ELISA, FC, ICC, Block, IHC.
- Application(s) Block, ELISA, FC, ICC, IHC
- Application Details The antibody binds specifically to α5β1 integrin, which is part of the superfamily of glycoprotein transmembrane receptors for ligands such as fibronectin, vitronectin, laminins and collagens. The α5β1 integrin receptor plays a key role in cellular processes such as inflammation, cell proliferation, angiogenesis and tumour metastasis. Comprising the variable domain of the original mouse antibody, a chimeric mouse:human IgG4 version of this antibody has been tested in vivo: In cynomolgus monkeys with laser-induced choroidal neovascularization (CNV), in rabbit models and in human volunteers. The antibody reached Phase II clinical trials with PDL Biopharma and Biogen-Idec.
- Target Integrin alpha-5
- Specificity The antibody binds to human α5β1 integrin with a Kd of 0.367 nM (determined by Biacore), an EC50 of 0.2 nM and an IC50 of 2.3 nM.
- Target Host Species Human
- Species Reactivity Human
- Antibody Host Human
- Antibody Type Recombinant
- Antibody Isotype IgG4, kappa
- Clone Name M200 (Volociximab)
- Conjugate Unconjugated
- Immunogen Description Heterodimeric α5β1Fc fusion protein
- Purity Description Purified antibody, via affinity chromatography
- Format Liquid. PBS with 0.02% Proclin 300.
- Concentration 1 mg/mL
- Storage Instructions Store at 2-8°C for up to 1 month. For longer storage, aliquot and store at -20_C. Avoid mulitiple freeze thaw cycles.
- Batch Number Please see item label.
- Expiration Date Store at 2-8⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C for up to 12 months.
- Alternative Names Fibronectin receptor; CD49 antigen-like family member E; Integrin alpha-F; VLA-5; CD49e.
- Uniprot Number P08648
- Uniprot Number/Name P08648 (ITA5_HUMAN)
- Scientific Background NOT FOR THERAPEUTIC USE - This is a research-grade biosimilar. The antibody binds specifically to α5β1-integrin, which is part of the superfamily of glycoprotein transmembrane receptors for ligands such as fibronectin, vitronectin, laminins and collagens. The α5β1-integrin receptor plays a key role in cellular processes such as inflammation, cell proliferation, angiogenesis and tumour metastasis. Comprising the variable domain of the original mouse antibody, a chimeric mouse:human IgG4 version of this antibody has been tested in vivo: In cynomolgus monkeys with laser-induced choroidal neovascularization (CNV), in rabbit models and in human volunteers. The antibody reached Phase II clinical trials with PDL Biopharma and Biogen-Idec.
- Shipping Temperature 2-8°C (on cold packs)
- UNSPSC CODE 41116161
- Regulatory Status For research use only.