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Signal transducer and activator of transcription 3, Mouse Monoclonal Antibody
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Catalog Number
M-870
- Product Name Signal transducer and activator of transcription 3, Mouse Monoclonal Antibody
- Product Description Mouse anti-Signal transducer and activator of transcription 3 Monoclonal Antibody (Unconjugated), suitable for WB, ELISA.
- Alternative Names Signal transducer and activator of transcription 3; STAT3; APRF
- Application(s) ELISA, WB
- Antibody Host Mouse
- Antibody Type Monoclonal
- Specificity Specificity has been confirmed by WB and direct ELISA against the antigen. Human. Other species have not been tested.
- Species Reactivity Human
- Immunogen Description Recombinant human Acute-phase response factor with GST tag.
- Conjugate Unconjugated
- Purity Description Protein G purified immunoglobulin
- Regulatory Status For research use only.
Product Info
- Product Description Mouse anti-Signal transducer and activator of transcription 3 Monoclonal Antibody (Unconjugated), suitable for WB, ELISA.
- Application(s) ELISA, WB
- Application Details This antibody is recommended for WB and ELISA. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
- Target Signal transducer and activator of transcription 3
- Specificity Specificity has been confirmed by WB and direct ELISA against the antigen. Human. Other species have not been tested.
- Target Host Species Human
- Species Reactivity Human
- Antibody Host Mouse
- Antibody Type Monoclonal
- Antibody Isotype IgG
- Clone Name 1D11
- Conjugate Unconjugated
- Immunogen Description Recombinant human Acute-phase response factor with GST tag.
- Purity Description Protein G purified immunoglobulin
- Format Lyophilized from PBS pH 7.2
- Reconstitution Instructions Spin vial briefly before opening. Reconstitute in 100 µL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material.
- Storage Instructions After reconstitution keep aliquots at -20°C for higher stability. Glycerol (1:1) may be added for additional stability. Avoid repetitive freeze/thaw cycles.
- Batch Number Please see item label.
- Expiration Date 12 months after date of receipt (unopened vial).
- Alternative Names Signal transducer and activator of transcription 3; STAT3; APRF
- Uniprot Number P40763
- Uniprot Number/Name P40763 (STAT3_HUMAN
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Scientific Background
Acute-phase response factor is a transcription factor that binds to the IL-6-responsive elements identified in the promoters of various acute-phase protein genes. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. Once phosphorylated, the protein is translocated into the nucleus. It forms a homodimer or a heterodimer with a related family member (STAT1). It is expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Defects in Acute-phase response factor are the cause of hyperimmunoglobulin E recurrent infection syndrome autosomal dominant (AD-HIES). This disorder is characterised by immunodeficiency, chronic eczema, recurrent Staphylococcal infections, increased serum IgE, eosinophilia, distinctive coarse facial appearance, abnormal dentition, hyperextensibility of the joints, and bone fractures.
- Shipping Temperature 25°C (ambient)
- UNSPSC CODE 41116161
- Regulatory Status For research use only.
