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Transcription factor AP-2-beta (AP2-beta), Mouse Monoclonal Antibody
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Catalog Number
M-872
- Product Name Transcription factor AP-2-beta (AP2-beta), Mouse Monoclonal Antibody
- Product Description Mouse anti-Transcription factor AP-2-beta (AP2-beta) Monoclonal Antibody (Unconjugated), suitable for WB, ELISA.
- Alternative Names Transcription factor AP2-beta; Activating enhancer-binding protein 2 beta; TFAP2B
- Application(s) ELISA, WB
- Antibody Host Mouse
- Antibody Type Monoclonal
- Specificity Specificity has been confirmed by WB and direct ELISA against the antigen. Human. Other species have not been tested.
- Species Reactivity Human
- Immunogen Description Recombinant human AP2-beta (amino acids 12-460) with GST tag.
- Conjugate Unconjugated
- Purity Description Protein G purified immunoglobulin
- Regulatory Status For research use only.
Product Info
- Product Description Mouse anti-Transcription factor AP-2-beta (AP2-beta) Monoclonal Antibody (Unconjugated), suitable for WB, ELISA.
- Application(s) ELISA, WB
- Application Details This antibody is recommended for WB and ELISA. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
- Target Transcription factor AP-2-beta (AP2-beta)
- Specificity Specificity has been confirmed by WB and direct ELISA against the antigen. Human. Other species have not been tested.
- Target Host Species Human
- Species Reactivity Human
- Antibody Host Mouse
- Antibody Type Monoclonal
- Antibody Isotype IgG
- Clone Name 3G5-1D11
- Conjugate Unconjugated
- Immunogen Description Recombinant human AP2-beta (amino acids 12-460) with GST tag.
- Purity Description Protein G purified immunoglobulin
- Format Lyophilized from PBS pH 7.2
- Reconstitution Instructions Spin vial briefly before opening. Reconstitute in 100 µL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material.
- Storage Instructions After reconstitution keep aliquots at -20°C for higher stability or at 2-8°C with an appropriate antibacterial agent. Glycerol (1:1) may be added for additional stability. Avoid repetitive freeze/thaw cycles.
- Batch Number Please see item label.
- Expiration Date 12 months after date of receipt (unopened vial).
- Alternative Names Transcription factor AP2-beta; Activating enhancer-binding protein 2 beta; TFAP2B
- Uniprot Number Q92481
- Uniprot Number/Name Q92481 (AP2B_HUMAN)
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Scientific Background
AP2-beta is a sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes during early development. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes. AP2-beta appears to be required for normal face and limb development and for proper termnal differentiation and function of renal tubular epithelia. Binds DNA as a dimer. It can form homodimers or heterodimers with other AP-2 family members. Defects in AP2-beta are the cause of Char syndrome (CHAR) which is characterised by patent ductus anteriosus (PDA), facial dysmorphism and hand anomalies.
- Shipping Temperature 25°C (ambient)
- UNSPSC CODE 41116161
- Regulatory Status For research use only.
