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Neurogenic locus notch homolog protein 1 (Notch 1), Rabbit Polyclonal Antibody
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Catalog Number
R-1128
- Product Name Neurogenic locus notch homolog protein 1 (Notch 1), Rabbit Polyclonal Antibody
- Product Description Rabbit anti-Neurogenic locus notch homolog protein 1 (Notch 1) Polyclonal Antibody (Unconjugated), suitable for WB.
- Alternative Names Neurogenic locus notch homolog protein 1; Notch 1; hN1; Translocation-associated notch protein TAN-1; NOTCH1; TAN1;
- Application(s) WB
- Antibody Host Rabbit
- Antibody Type Polyclonal
- Specificity The specificity of this antibody has been confirmed by WB against the antigen. Human;
- Species Reactivity Human
- Immunogen Description A synthetic peptide (HTNVVFKRDAHGQQMIFPY) corresponding to a region (1601-1619) from human Notch 1 (precursor). To enhance the immunological response, this peptide was coupled to carrier protein BSA.
- Conjugate Unconjugated
- Purity Description Affinity purified on antigen column
- Regulatory Status For research use only.
Product Info
- Product Description Rabbit anti-Neurogenic locus notch homolog protein 1 (Notch 1) Polyclonal Antibody (Unconjugated), suitable for WB.
- Application(s) WB
- Application Details Western Blotting (WB). A concentration of 1.0 µg/mL is recommended for WB. Human Notch 1 (precursor) has a predicted length of 2,555 residues and MW of 273 kDa. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
- Target Neurogenic locus notch homolog protein 1 (Notch 1)
- Specificity The specificity of this antibody has been confirmed by WB against the antigen. Human;
- Target Host Species Human
- Species Reactivity Human
- Antibody Host Rabbit
- Antibody Type Polyclonal
- Antibody Isotype IgG
- Conjugate Unconjugated
- Immunogen Description A synthetic peptide (HTNVVFKRDAHGQQMIFPY) corresponding to a region (1601-1619) from human Notch 1 (precursor). To enhance the immunological response, this peptide was coupled to carrier protein BSA.
- Purity Description Affinity purified on antigen column
- Format Lyophilized with 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg NaN3
- Reconstitution Instructions Spin vial briefly before opening. Reconstitute in 100 µL sterile-filtered, ultrapure water to achieve an antibody concentration of 1 mg/mL. Centrifuge to remove any insoluble material.
- Storage Instructions At least 12 months after purchase at 2-8°C (lyophilized formulations). After reconstitution, aliquot and store at -20°C for a higher stability. Avoid freeze-thaw cycles.
- Batch Number Please see item label.
- Expiration Date 12 months after date of receipt (unopened vial).
- Alternative Names Neurogenic locus notch homolog protein 1; Notch 1; hN1; Translocation-associated notch protein TAN-1; NOTCH1; TAN1;
- Uniprot Number P46531
- Uniprot Number/Name P46531 (NOTC1_HUMAN)
- Scientific Background Notch 1 is initially synthesized as inactive precursor molecule. During maturation, the molecule is cleaved at its extracellular domain. Upon binding to a ligand such as Delta1, a C-terminal Notch 1 fragment is released and further cleaved. The resulting activated cytosolic fragment translocates to the nucleus where it activates transcription. Notch 1 is mostly found in fetal spleen, brain stem and lung tissues and adult lymphoid tissues.
- Shipping Temperature 25°C (ambient)
- UNSPSC CODE 41116161
- Regulatory Status For research use only.
