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Tyrosine Kinase Receptor B (TrkB)-Fc Chimera, Human, Purified Recombinant Protein
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Catalog Number
PE-1236
- Product Name Tyrosine Kinase Receptor B (TrkB)-Fc Chimera, Human, Purified Recombinant Protein
- Product Description Tyrosine Kinase Receptor B (TrkB)-Fc Chimera, Human, Purified Recombinant Protein, suitable to Block..
- Alternative Names Tropomyosin-related kinase receptor; NT-3 growth factor receptor; Neurotrophic tyrosine kinase receptor type 3; TrkC tyrosine kinase; GP145-TrkC; Trk-C; NTRK3; TRKC; TrkC-Fc Chimera
- Application(s) Block
- Purity Description >95%, as determined by SDS-PAGE and visualized by silver stain.
- Purity % > 95%
- Regulatory Status For research use only.
Product Info
- Product Description Tyrosine Kinase Receptor B (TrkB)-Fc Chimera, Human, Purified Recombinant Protein, suitable to Block..
- Application(s) Block
- Target Tyrosine Kinase Receptor C (TrkC)
- Target Host Species Human
- Antigen Produced In HEK293
- Sequence A DNA sequence encoding the signal peptide and extracellular domain of human TrkC (amino acids 1-428) was fused to the Fc region of human IgG1 (amino acids 93-330). The chimeric protein was expressed in modified human 293 cells.
- Purity Description >95%, as determined by SDS-PAGE and visualized by silver stain.
- Purity % > 95%
- Format The TrkC-Fc chimera consists of 15-55% carbohydrate by weight. When reconstituted in 0.5 mL sterile phosphate-buffered saline, the solution will contain 1% human serum albumin (HSA) and 10% trehalose.
- Reconstitution Instructions It is recommended that 0.5 mL of sterile phosphate-buffered saline be added to the vial.
- Storage Instructions Lyophilized products should be stored at 2 to 8°C. Following reconstitution short-term storage at 2-8°C is recommended, and longer-term storage of aliquots at -18 to -20°C. Repeated freeze thawing is not recommended.
- Batch Number Please see item label.
- Expiration Date 12 months after date of receipt (unopened vial).
- Alternative Names Tropomyosin-related kinase receptor; NT-3 growth factor receptor; Neurotrophic tyrosine kinase receptor type 3; TrkC tyrosine kinase; GP145-TrkC; Trk-C; NTRK3; TRKC; TrkC-Fc Chimera
- Uniprot Number Q16288
- Uniprot Number/Name Q16288 (NTRK3_HUMAN)
- Scientific Background TrkC is a member of the tropomyosin-related kinase receptor family. TrkC is a membrane-bound receptor that upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. TrkC is the receptor for neurotrophin-3 (NT-3). Signalling through TrkC leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. TrkC is a heavily glycosylated molecule with 13 potential N-linked glycosylation sites within the extracellular domain.
- Shipping Temperature 25°C (ambient)
- UNSPSC CODE 12352202
- Regulatory Status For research use only.
