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NGFR/p75 neurotrophin receptor (p75NTR)-Fc Chimera (209 amino acids), Purified Recombinant Protein
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Catalog Number
PE-1237
- Product Name NGFR/p75 neurotrophin receptor (p75NTR)-Fc Chimera (209 amino acids), Purified Recombinant Protein
- Product Description p75 neurotrophin receptor (p75NTR)-Fc Chimera (209 amino acids), Purified Recombinant Protein, suitable to Block.
- Alternative Names Low-affinity nerve growth factor receptor; NGF receptor; Gp80-LNGFR; p75 ICD; Low affinity neurotrophin receptor p75NTR; p75NTR; CD271;
- Application(s) Block
- Purity Description >95%, as determined by SDS-PAGE and visualized by silver stain
- Purity % > 95%
- Regulatory Status For research use only.
Product Info
- Product Description p75 neurotrophin receptor (p75NTR)-Fc Chimera (209 amino acids), Purified Recombinant Protein, suitable to Block.
- Application(s) Block
- Target NGFR/p75 neurotrophin receptor (p75NTR)
- Target Host Species Human
- Antigen Produced In HEK293
- Sequence A DNA sequence encoding the signal peptide and extracellular domain of human NGF receptor (amino acids 1-237) was fused to the Fc region of human IgG1 (amino acids 93-330). The chimeric protein was expressed in modified human 293 cells.
- Purity Description >95%, as determined by SDS-PAGE and visualized by silver stain
- Purity % > 95%
- Format The NGF Receptor-Fc chimera consists of 25-45% carbohydrate by weight.
- Reconstitution Instructions It is recommended that 0.5 mL of sterile phosphate-buffered saline (PBS) be added to the vial. When reconstituted in 0.5mL of PBS, the solution will contain 1% human serum albumin (HSA) and 10% trehalose.
- Storage Instructions Lyophilized products should be stored at 2-8°C. Following reconstitution, short-term storage at 2-8°C is recommended and longer-term storage of aliquots at -18 to -20°C. Repeated freeze thawing is not recommended.
- Batch Number Please see item label.
- Expiration Date 12 months after date of receipt (unopened vial).
- Alternative Names Low-affinity nerve growth factor receptor; NGF receptor; Gp80-LNGFR; p75 ICD; Low affinity neurotrophin receptor p75NTR; p75NTR; CD271;
- Uniprot Number P08138
- Uniprot Number/Name P08138 (TNR16_HUMAN)
- Scientific Background Nerve growth factor (NGF) receptor, also known as p75NTR, is a low affinity NGF receptor. It binds with equal affinity neurotrophins such as beta NGF, BDNF, NT-3 and NT-4. NGF receptors mediate signaling of neurotrophins for neuronal survival, apoptosis, neurite outgrowth and synaptic plasticity. These receptors are also thought to play a role in neurogenerative diseases such as Alzheimers disease. The NGF receptor is a type I transmembrane glycoprotein (399 aa) consisting of a signal peptide (28 aa), an extracellular domain (222 aa) which contains four cysteine rich domains responsible for ligand binding, a transmembrane domain (22 aa) and a cytoplasmic domain (155 aa).
- Shipping Temperature 25°C (ambient)
- UNSPSC CODE 12352202
- Regulatory Status For research use only.