Tyrosine Kinase Receptor A (TrkA)-Fc Chimera, Purified Recombinant Protein

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Catalog Number
PE-1248

    Product Info

  • Product Name Tyrosine Kinase Receptor A (TrkA)-Fc Chimera, Purified Recombinant Protein
  • Product Description google Tyrosine Kinase Receptor A (TrkA)-Fc Chimera, Purified Recombinant Protein, suitable to Block.
  • Alternative Names Tropomyosin-related kinase receptor; High affinity nerve growth factor receptor; Neurotrophic tyrosine kinase receptor type 1; TRK1 transforming tyrosine kinase protein; p140-TrkA; Trk-A; NTRK1; TRK
  • Application(s) Block
  • Purity Description >95%, as determined by SDS-PAGE.
  • Purity % > 95%
  • Regulatory Status For research use only.

    Specifications

  • Product Description Tyrosine Kinase Receptor A (TrkA)-Fc Chimera, Purified Recombinant Protein, suitable to Block.
  • Application(s) Block
  • Target Tyrosine Kinase Receptor A (TrkA)
  • Target Host Species Human
  • Antigen Produced In HEK293
  • Sequence A DNA sequence encoding the signal peptide and extracellular domain of human TrkA (amino acids 1- 413) was fused to the Fc region of human IgG1 (amino acids 104-330). The chimeric protein was expressed in modified human 293 cells.
  • Purity Description >95%, as determined by SDS-PAGE.
  • Purity % > 95%
  • Format Protein G purified.
  • Reconstitution Instructions Spin vial briefly before opening. Reconstitute with sterile PBS, pH 7.4 to give a concentration of 0.5 mg/mL.
  • Storage Instructions Lyophilized product should be stored at 2 to 8°C. Following reconstitution, short-term storage at 2-8°C is recommended and longer-term storage of aliquots at -18 to -20°C. Repeated freeze thawing is not recommended.
  • Batch Number Please see item label.
  • Expiration Date 12 months after date of receipt (unopened vial).
  • Alternative Names Tropomyosin-related kinase receptor; High affinity nerve growth factor receptor; Neurotrophic tyrosine kinase receptor type 1; TRK1 transforming tyrosine kinase protein; p140-TrkA; Trk-A; NTRK1; TRK
  • Uniprot Number P04629
  • Uniprot Number/Name P04629 (NTRK1_HUMAN)
  • Scientific Background TrkA is a member of the neurotrophic tyrosine kinase receptor family. It is a membrane-bound receptor that upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. TrkA is required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). TrkA leads to cell differentiations and may play a role in specifying sensory neuron subtypes. It has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. SUBUNIT: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. SUBCELLULAR LOCATION: TrkA is a heavily glycosylated transmembrane protein and contains 13 potential N-linked glycosylation sites. The TrkA-Fc chimera has N-linked and may have O-linked oligosaccharides.
  • Shipping Temperature 25°C (ambient)
  • UNSPSC CODE 12352202
  • Regulatory Status For research use only.

    Images, Protocols & SDS

  • Gel analysis of TrkA-Fc Chimera.

    Lane 1: MW marker
    Lane 2: TrkA-Fc Chimera (20 µg), non-reducing
    Lane 3: TrkA-Fc Chimera (20 µg), reducing condition

    Citations & References