Camostat Mesylate, Purified Small Molecule

Only %1 left
Catalog Number
PE-1841
Discontinued

    Product Info

  • Product Name Camostat Mesylate, Purified Small Molecule
  • Product Description google Camostat Mesylate, Purified Small Molecule, suitable to Neutralize.
  • Alternative Names Camostat Methanesulfonate;Camostat (mesylate); FOY 305; FOY-305; Foipan; CAS 59721-29-8
  • Application(s) Neutralize
  • Purity Description >98% by HPLC; NMR (Conforms)
  • Purity % > 98%
  • Regulatory Status For research use only.

    Specifications

  • Product Description Camostat Mesylate, Purified Small Molecule, suitable to Neutralize.
  • Application(s) Neutralize
  • Application Details Trypsin-like protease inhibitor. Reversibly inhibits airway epithelial sodium channel (ENaC) function (IC50 = 50 nM). Inhibits the production of TNF-alpha and monocyte chemoattractant protein-1 (MCP-1) by monocytes and disrupts proliferation of pancreatic stellate cells in a rat model of pancreatic fibrosis.
  • Target Camostat Mesylate
  • Target Host Species Species Independent
  • Purity Description >98% by HPLC; NMR (Conforms)
  • Purity % > 98%
  • Format Dry powder; Off-white powder
  • Reconstitution Instructions Soluble in water or DMSO. May be dissolved in DMSO up to 50 mg/mL, or water (50 mg/mL)
  • Storage Instructions Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 1 month. Prevent multiple freeze-thaw cycles.
  • Batch Number Please see item label.
  • Expiration Date Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 1 month. Prevent multiple freeze-thaw cycles.
  • Alternative Names Camostat Methanesulfonate;Camostat (mesylate); FOY 305; FOY-305; Foipan; CAS 59721-29-8
  • Scientific Background Pharmacology: A serine protease inhibitor inhibiting plasmin, kallikrein, thrombin as well as trypsin, which attenuates pancreatic fibrosis (1). Reduces weight gain and improves metabolism in obese rodent models (2). In clinical use (in Japan) for pancreatitis (3). Inhibits influenza virus replication in human tracheal epithelial cells (4). Reduces infection of Calu-3 lung cells by SARS-CoV-2 (responsible for COVID-19) via inhibition of the serine protease TMPRSS2 required for viral spike protein priming (5). PubChem CID: 5284360

    Product is sold for research use only. Not for human therapeutic use or for medicinal purposes.
  • Shipping Temperature 25°C (ambient)
  • UNSPSC CODE 12352401
  • Regulatory Status For research use only.

    Citations & References

  • General References J Gibo et al. Lab. Invest. 2005 85:75
    K Albarazanji et al. Am. J. Physiol. Gastrointest. Liver Physiol. 2019 316:G653
    M Ueda et al. Nephron 2015 129:223
    M Yamaya et al. Pulm. Pharmacol. Ther. 2015 33:66