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Nelfinavir Mesylate (NFV), Purified Small Molecule

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Catalog Number
PE-1847
Discontinued

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    Product Info

  • Product Name Nelfinavir Mesylate (NFV), Purified Small Molecule
  • Product Description google Nelfinavir Mesylate (NFV), Purified Small Molecule, suitable to Neutralize.
  • Alternative Names Methanesulfonate; AG-1343; Nelfinavir; CAS 159989-65-8
  • Application(s) Neutralize
  • Purity Description >98% (HPLC); NMR (Conforms)
  • Purity % > 98%
  • Regulatory Status For research use only.

    Specifications

  • Product Description Nelfinavir Mesylate (NFV), Purified Small Molecule, suitable to Neutralize.
  • Application(s) Neutralize
  • Application Details Human immunodeficiency virus protease inhibitor. Potently inhibits HIV-1 protease (Ki = 2 nM) in vitro (5).
  • Target Nelfinavir Mesylate (NFV)
  • Target Host Species Species Independent
  • Purity Description >98% (HPLC); NMR (Conforms)
  • Purity % > 98%
  • Format Dry, white powder.
  • Reconstitution Instructions Soluble in DMSO. May be dissolved in DMSO up to 70 mg/mL.
  • Storage Instructions Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 1 month. Prevent multiple freeze-thaw cycles.
  • Batch Number Please see item label.
  • Expiration Date Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 1 month. Prevent multiple freeze-thaw cycles.
  • Alternative Names Methanesulfonate; AG-1343; Nelfinavir; CAS 159989-65-8
  • Scientific Background Pharmacology: Nelfinavir is a clinically useful anti-HIV agent acting via inhibition of HIV-1 protease (Ki=2 nM) (1). It also displays efficacy in cancer, malaria, tuberculosis and SARS (2). Displays broad spectrum anticancer activity and induces endoplasmic reticulum stress, autophagy and apoptosis in vitro and in vivo (3). Inhibits the growth of HER2-positive breast cancer cells via inhibition of HSP90 through a novel mechanism (4). PubChem CID: 64142.

    Product is sold for research use only, Not for human therapeutic use or for medicinal purposes.
  • Shipping Temperature 25°C (ambient)
  • UNSPSC CODE 12352401
  • Regulatory Status For research use only.

    Citations & References

  • General References M Olmo and D Podzamczer Expert Opin. Drug Metab. Toxicol. 2006 2:285.
    A Bruening et al. Curr. Mol. Pharmacol. 2010 3:91.
    JJ Gills et al. Clin. Cancer Res. 2007 13:5183.
    JS Shim et al. J. Natl. Cancer Inst. 2012 104:1576.
    Kaldor SW, et al.J Med Chem, 1997,40(24):3979-85.