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Nitazoxanide, Purified Small Molecule

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Catalog Number
PE-1849
Discontinued

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    Product Info

  • Product Name Nitazoxanide, Purified Small Molecule
  • Product Description google Nitazoxanide, Purified Small Molecule, suitable to Neutralize.
  • Alternative Names NTZ; CAS 55981-09-4
  • Application(s) Neutralize
  • Purity Description >98% (HPLC); NMR (Conforms)
  • Purity % > 98%
  • Regulatory Status For research use only.

    Specifications

  • Product Description Nitazoxanide, Purified Small Molecule, suitable to Neutralize.
  • Application(s) Neutralize
  • Application Details NTZ demonstrates IC50 values of 2.5 and 10 uM for Giardia and Cryptosporidium, respectively. Additionally, NTZ kills replicating and nonreplicating M. tuberculosis with an IC50 value of 1 uM, while seemingly evading the development of resistance (6).
  • Target Nitazoxanide
  • Target Host Species Species Independent
  • Purity Description >98% (HPLC); NMR (Conforms)
  • Purity % > 98%
  • Format Dry, white powder.
  • Reconstitution Instructions Soluble in DMSO. May be dissolved in DMSO up to 50 mg/mL.
  • Storage Instructions Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 1 month. Prevent multiple freeze-thaw cycles.
  • Batch Number Please see item label.
  • Expiration Date Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 1 month. Prevent multiple freeze-thaw cycles.
  • Alternative Names NTZ; CAS 55981-09-4
  • Scientific Background Pharmacology: Nitazoxanide is a clinically useful antiparasitic agent (1). It has since been repurposed as a broad-spectrum antiviral agent that is active against many RNA and DNA viruses including influenza, hepatitis B and C, RSV, coronavirus, dengue and others (2). Its antiparasitic activity is believed to be due to inhibition of pyruvate:ferredoxin/flavodoxin oxidoreductases (3). Antiviral activity involves activation of protein kinase activated by double- stranded RNA (PKR) leading to phosphorylation of eukaryotic initiation factor 2 alpha (eIF2_) (4). Nitazoxanide has also been found to inhibit Wnt signaling independent of adenomatous polyposis coli (APC), targeting peptidyl arginine deiminase 2 (PAD2) resulting in increased citrullination of _-catenin (5). PubChem CID: 41684.

    Product is sold for research use only. Not for human therapeutic use or for medicinal purposes.

    InChI
    InChI=1S/C12H9N3O5S/c1-7(16)20-9-5-3-2-4-8(9)11(17)14-12-13-6-10(21-12)15(18)19/h2-6H,1H3,(H,13,14,17)

    InChI Key
    YQNQNVDNTFHQSW-UHFFFAOYSA-N

    Canonical SMILES
    CC(=O)OC1=CC=CC=C1C(=O)NC2=NC=C(S2)[N+](=O)[O-]
  • Shipping Temperature 25°C (ambient)
  • UNSPSC CODE 12352401
  • Regulatory Status For research use only.

    Citations & References

  • General References CA White Expert Rev. Anti. Infect. Ther. 2004 2:43
    J-F Rossignol Antiviral Res. 2014 110:94
    PS Hoffman et al. Antimicrob. Agents Chemother. 2007 51:868
    M Elazar et al. Gastroenterology 2009 137:1827
    Y Qu et al. Nat. Chem. Biol. 2018 14:94
    de Carvalho.,et al. 2009. J. Med. Chem.ﾠ52(19),ﾠ5789-5792