Bright field illumination (60X mag) of 8 month old Ad-Tg mouse hippocampus. The myelin pathology can be observed in and around amyloid plaques. The cell bodies of adjacent granule and polymorph cells appear blue, while individual myeliated fibres appear nearly black. Photo is courtesy of Dr. Larry Schmued.
Human brain Locus K (Del Fiacco et al., Brain Struct Funct. 2014, 2019: 2083-2101; Cells 2018, 7, 72): calcitonin gene-related peptide-like immunoreactivity (black) and myelin staining (red, Black-Gold II staining kit, Biosensis) in the medulla oblongata, showing the similar neurochemical and structural organization of the dorsal column nuclei Locus K and the spinal trigeminal substantia gelatinosa.