D: Within the CA4 region of the hippocampus, co-labeling using GFAP antibody demonstrates the relationship between hypertrophied astrocytes (orange) and the amyloid plaques (green) that they typically surround. GFAP-immunoreactivity was visualized with TRITC fluorophore. E: Three amyloid plaques (green) are seen in the cortex of a human with Alzheimer's disease. F: An example of vascular plaques in the cortex of a human AD patient.
HQ-O stained plaques can be seen within the CA-1 region of the hippocampus (D). This same field of view stained with immunofluorescent methods using the Aβx-40/42 MOAB-2 antibody, M-1586-100. Biosensis antibody reveals a similar but somewhat more restricted labeling of the same amyloid plaques (E), which is apparent when the images are merged (F). Photo taken with permission from Current Alzheimer Research, 2019, Vol. 16, No. 7 583, Figure 4.