Product DescriptionRabbit anti-A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS-4) Polyclonal Antibody (Unconjugated), suitable for WB.
Application(s)WB
Application DetailsWestern Blotting (WB). A concentration of 0.1-0.5 µg/mL is recommended for WB. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
TargetA disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS-4)
SpecificityThe specificity of this antibody has been confirmed by WB against the antigen. Human; Rat; Mouse;
Target Host SpeciesHuman
Species ReactivityHuman, Mouse, Rat
Antibody HostRabbit
Antibody TypePolyclonal
Antibody IsotypeIgG
ConjugateUnconjugated
Immunogen DescriptionA synthetic peptide corresponding to a region (820-837 aa) from the C-terminus of human ADAMTS-4.
Purity DescriptionAffinity purified on antigen column
Reconstitution InstructionsSpin vial briefly before opening. Reconstitute in 100 µL sterile-filtered, ultrapure water to achieve an antibody concentration of 1 mg/mL. Centrifuge to remove any insoluble material.
Storage InstructionsStore lyophilized antibody at 2-8°C. After reconstitution divide into aliquots and store at -20°C for long-term storage. Store at 2-8°C short-term (up to 4 weeks) with an appropriate antibacterial agent. Avoid repetitive freeze/thaw cycles.
Batch NumberPlease see item label.
Expiration Date12 months after date of receipt (unopened vial).
Alternative NamesA disintegrin and metalloproteinase with thrombospondin motifs 4; ADAMTS-4; ADAM-TS 4; ADAM-TS4; EC 3.4.24.82; Aggrecanase-1; Adamts4; ADAMTS4;
Scientific BackgroundADAMTS-4 is a glutamyl endopeptidase that cleaves aggrecan and brevican. The degradation of aggrecan, a cartilage proteoglycan, has been linked to rheumatoid arthritis, osteoarthritis, retinal diseases, Alzheimers disease and other neurodegenerative diseases.