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Runt-related transcription factor 2 (RUNX2), Rabbit Polyclonal Antibody
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Catalog Number
R-1133
- Product Name Runt-related transcription factor 2 (RUNX2), Rabbit Polyclonal Antibody
- Product Description Rabbit anti-Runt-related transcription factor 2 (RUNX2) Polyclonal Antibody (Unconjugated), suitable for WB.
- Alternative Names Core-binding factor subunit alpha-1; CBF-alpha-1; Acute myeloid leukemia 3 protein; Oncogene AmL-3; Polyomavirus enhancer-binding protein 2 alpha A subunit; PEBP2-alpha A; PEA2-alpha A; SL3-3 enhancer factor 1 alpha A subunit; SL3/AKV core-binding factor alpha A subunit; Osteoblast-specific transcription factor 2; OSF-2; RUNX2; AmL3; CBFA1; OSF2; PEBP2A;
- Application(s) WB
- Antibody Host Rabbit
- Antibody Type Polyclonal
- Specificity The specificity of this antibody has been confirmed by WB against the antigen. Human; rat; predicted to react with mouse due to sequence homology;
- Species Reactivity Human, Mouse (Predicted), Rat
- Immunogen Description A synthetic peptide corresponding to a region (244-258 aa) from human Runt-related transcription factor 2. To enhance the immunological response, this peptide was coupled to carrier protein BSA.
- Conjugate Unconjugated
- Purity Description Affinity purified on antigen column
- Regulatory Status For research use only.
Product Info
- Product Description Rabbit anti-Runt-related transcription factor 2 (RUNX2) Polyclonal Antibody (Unconjugated), suitable for WB.
- Application(s) WB
- Application Details Western Blotting (WB). A concentration of 0.1-0.5 µg/mL is recommended for WB. Human RUNX2 (isoform 1) has a predicted length of 521 residues and MW of 57 kDa.
- Target Runt-related transcription factor 2 (RUNX2)
- Specificity The specificity of this antibody has been confirmed by WB against the antigen. Human; rat; predicted to react with mouse due to sequence homology;
- Target Host Species Human
- Species Reactivity Human, Mouse (Predicted), Rat
- Antibody Host Rabbit
- Antibody Type Polyclonal
- Antibody Isotype IgG
- Conjugate Unconjugated
- Immunogen Description A synthetic peptide corresponding to a region (244-258 aa) from human Runt-related transcription factor 2. To enhance the immunological response, this peptide was coupled to carrier protein BSA.
- Purity Description Affinity purified on antigen column
- Format Lyophilized with 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg NaN3
- Reconstitution Instructions Spin vial briefly before opening. Reconstitute in 100 µL sterile-filtered, ultrapure water to achieve an antibody concentration of 1 mg/mL. Centrifuge to remove any insoluble material.
- Storage Instructions At least 12 months after purchase at 2-8°C (lyophilized formulations). After reconstitution, aliquot and store at -20°C for a higher stability. Avoid freeze-thaw cycles
- Batch Number Please see item label.
- Expiration Date 12 months after date of receipt (unopened vial).
- Alternative Names Core-binding factor subunit alpha-1; CBF-alpha-1; Acute myeloid leukemia 3 protein; Oncogene AmL-3; Polyomavirus enhancer-binding protein 2 alpha A subunit; PEBP2-alpha A; PEA2-alpha A; SL3-3 enhancer factor 1 alpha A subunit; SL3/AKV core-binding factor alpha A subunit; Osteoblast-specific transcription factor 2; OSF-2; RUNX2; AmL3; CBFA1; OSF2; PEBP2A;
- Uniprot Number Q13950
- Uniprot Number/Name Q13950 (RUNX2_HUMAN)
- Scientific Background Runt-related transcription factor 2 (RUNX2) is a member of the RUNX family of transcription factors. RUNX2 has an Runt domain and can bind DNA both as a monomer or as a subunit of a heterodimeric complex. RUNX2 has a role in osteoblastic differentiation and skeletal morphogenesis and is essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. RUNX2 is specifically expressed in the nucleus of osteoblasts. At least 3 isoforms are produced by alternative splicing.
- Shipping Temperature 25°C (ambient)
- UNSPSC CODE 41116161
- Regulatory Status For research use only.